蛋白激酶CK2的结构及其生理功能研究进展

Advances in the structure and physiological function of protein kinase CK2

蛋白激酶CK2是一种常见的、进化保守的、普遍存在的蛋白激酶。近年来,越来越多的研究表明CK2具有多种磷酸化蛋白底物,这些底物在生长发育及各类疾病中都具有重要的作用,因此CK2可以通过调控这些底物的磷酸化参与这些生理过程。文中简要综述了蛋白激酶CK2的结构特征及其在生长发育、免疫、肿瘤等疾病中的生理功能,以期为进一步研究CK2的调控机制和应用提供理论依据。

Protein kinase CK2 is a common,evolutionarily conserved and ubiquitous protein kinase.In recent years,increasing evidences have shown that CK2 has a variety of phosphorylated protein substrates,which play important roles in growth,development and various diseases.Therefore,CK2 may participate in these physiological processes by regulating the phosphorylation of these substrates.This article briefly reviewed the structural characteristics of protein kinase CK2 and its physiological functions in growth,development,immunity,formation of tumor and other diseases,in order to provide knowledge basis for further research on the regulatory mechanism of CK2 and potential applications of its inhibitors.