福清市某镇常住居民高尿酸血症流行现况及相关因素分析

Prevalence and Related Factors of Hyperuricemia in a Town of Fuqing City

目的调查福清市高山镇常住居民高尿酸血症(HUA)的患病率,探讨HUA患病的相关因素。方法收集2019年参加"福清市居民慢性病前瞻性队列研究"的居民资料,统计不同分组人群HUA患病率,采用logistic回归模型分析HUA患病的相关因素。结果研究对象共5 172例,男性占34.05%,50岁以上者占79.95%。HUA年龄标化患病率为31.04%,男性年龄标化患病率高于女性(42.47%vs 27.36%),女性HUA患病率随年龄增长呈上升趋势。男性中,冠状动脉粥样硬化性心脏病(冠心病)、体质量指数(BMI)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、血清肌酐(Cr)与HUA呈正相关,空腹血糖与HUA呈负相关。女性中,年龄、BMI、TG、LDL-C、Cr与HUA呈正相关,高密度脂蛋白胆固醇与HUA呈负相关。结论福清市高山镇常住居民HUA患病率高于福建省平均水平(24.7%),HUA与血脂/血糖异常、超重肥胖和冠心病等病理生理过程有关,肾功能异常影响尿酸排泄。

Objective To investigate the prevalence of hyperuricemia(HUA) among permanent residents in Gaoshan Towm, Fuqing City, and to explore the related factors of HUA. Methods Data of residents who participated in the “Prospective Cohort Study of Chronic Diseases of Residents in Fuqing City” in 2019 were collected. The prevalence of HUA in different groups was calculated and logistic regression model was used to analyze the related factors of HUA. Results Of 5 172 residents, 34.05% residents were male and 79.95% residents aged over 50 years. The age-standardized prevalence of HUA was 31.04% and it was significantly higher in males than that in females(42.47% vs 27.36%). The prevalence of HUA increased with age in females. Presence of coronary heart disease, body mass index(BMI), triglyceride(TG), low density lipoprotein cholesterol(LDL-C) and creatinine(Cr) had positive correlation and fasting plasma glucose had negative correlation with HUA in males. Age, BMI, TG, LDL-C and Cr had positive correlation and high-density lipoprotein cholesterol had negative correlation with HUA in females. Conclusions The prevalence of HUA among permanent residents in Gaoshan Town, Fuqing City was higher than the average level of Fujian Province(24.7%). HUA was related to dyslipidemia, abnormal blood glucose, overweight/obesity, prevalent coronary heart disease and abnormal renal function.