炎症细胞因子白介素-6、肿瘤坏死因子-α、转化生长因子-β1在多囊卵巢综合征中作用机制及临床意义的研究进展

Research progress of the mechanism and clinical significance of inflammatory cytokines IL-6, TNF-α, TGF-β1 in polycystic ovary syndrome

多囊卵巢综合征(PCOS)是妇科常见的一种内分泌紊乱疾病,近年来的研究发现其发病率正在逐年上升,对女性的生活质量产生了不同程度的影响。PCOS的发病机制复杂多样,目前仍未明确,故其治疗也缺乏针对性及特异性。但慢性炎症在其发病机制中的重要作用已经被证实,本文通过检索近年来的国内外相关文献,主要从与炎症密切相关的细胞因子[包括白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和转化生长因子-β1(TGF-β1)]角度探讨其在PCOS中的作用机制及临床意义。

Polycystic ovary syndrome(PCOS) is a common endocrine disorder in gynecology. In recent years, it has been found that the incidence of PCOS is increasing year by year, which has affected women′s quality of life in various degrees. The pathogenesis of PCOS is complex and diverse, and has not been clearly defined at present, so its treatment lacks pertinency and specificity. However, the important role of chronic inflammation in its pathogenesis has been confirmed. In this paper, the mechanism and clinical significance of interleukin-6(IL-6), tumor necrosis factor-α(TNF-α) and transforming growth factor-β1(TGF-β1), which are closely related to inflammation, were explored by searching relevant literatures at home and abroad in recent years.