乳腺癌患者女性性功能障碍的发生率及其影响因素分析

Incidence and influence factors of female sexual dysfunction caused by breast cancer

目的探讨乳腺癌患者女性性功能障碍(FSD)的发生率及其影响因素。方法选取2016年1月1日至2020年12月31日上海交通大学医学院附属第九人民医院黄浦分院收治的217例乳腺癌患者作为研究对象,按照治疗后有无FSD分为FSD组(n=149)和非FSD组(n=68)。采用亚利桑那性体验量表(ASEX)、广泛性焦虑自评量表(GAD-7)、患者健康问卷-9(PHQ-9)、乳腺癌患者性调节和身体意象量表(SABIS)收集两组患者的信息,并进行单因素分析和多元线性回归分析。结果 149例(68.7%)女性乳腺癌患者发生FSD。两组患者确诊年龄、患乳腺癌前ASEX评分、GAD-7评分、PHQ-9评分、SABIS-1评分、SABIS-2评分比较,差异具有统计学意义(P<0.05)。单因素分析和多元线性回归分析显示,SABIS-2评分低和患乳腺癌前ASEX评分>14分是患乳腺癌后导致FSD发生的独立危险因素。结论女性乳腺癌患者患病后FSD发生率较高,其发生主要受患者自身性体验和性调节的影响。

Objective To investigate incidence and influence factors of female sexual dysfunction(FSD) among female breast cancer patients. Methods 217 breast cancer patients admitted to Huangpu Branch of Shanghai Ninth People′s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from January 1, 2016 to December 31, 2020 were selected as research subjects, and were divided into FSD group(n=149) and non-FSD group(n=68) according to whether FSD was present after treatment. The data of 2 groups was collected by Arizona sexual experience scale(ASEX), the generalized anxiety disorder-7(GAD-7), patient health questionnaire-9(PHQ-9), and breast cancer patient sexual adjustment and body image scale(SABIS). Univariate analysis and multiple linear regression analysis were performed. Results FSD occurred in 149(68.7%) female breast cancer patients. There were statistically significant differences in age of diagnosis, ASEX score before breast cancer, GAD-7 score, PHQ-9 score, SABIS-1 score and SABIS-2 score between 2 groups(P<0.05). Univariate analysis and multiple linear regression analysis showed that low SABIS-2 score and ASEX score >14 were independent risk factors for the development of FSD after breast cancer. Conclusions The incidence of FSD in female breast cancer patients is high, which is mainly affected by their own sexual experience and sexual regulation.