固体脂质纳米增强抗菌药物对胞内金黄色葡萄球菌活性的研究进展

Research Progress of Solid Lipid Nanoparticles Enhancing Antibacterial Activity against Intracellular Staphylococcus aureus

金黄色葡萄球菌导致的乳房炎是危害奶牛养殖业最严重的疾病之一。抗菌药在胞内极易排出或失活,导致奶牛金黄色葡萄球菌乳房炎治疗效果差且容易复发。纳米粒子具有在巨噬细胞和上皮细胞等多种细胞中积累的能力,可提高药物在胞内的浓度和胞内停留时间,这使得它们可用于治疗细胞内感染。本文对固体脂质纳米抗金黄色葡萄球菌感染的研究进展进行综述,以指导和推动固体脂质纳米在治疗金黄色葡萄球菌乳腺炎方面的应用。

Mastitis caused by Staphylococcus aureus is one of the most serious diseases affecting dairy cattle breeding.Antibacterials are easily discharged or inactivated in cells,which leads to poor therapeutic effects and easy recurrence of Staphylococcus aureus mastitis in dairy cows.Nanoparticles have the ability to accumulate in macrophages,epithelial cells and other cells,which can improve the intracellular concentration and intracellular residence time of drugs,which makes them useful for treating intracellular infections.In order to guide and promote the application of solid lipid nanoparticles in the treatment of Staphylococcus aureus mastitis,the research progress of solid lipid nanoparticles against Staphylococcus aureus infection is reviewed in this paper.