清肺降逆汤治疗慢性阻塞性肺疾病急性加重期的有效性

Efficacy of Qingfei Jiangni Decoction in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的研究清肺降逆汤治疗慢性阻塞性肺疾病急性加重期的临床疗效。方法现选取的研究对象是医院在2019年5月-2020年7月收治的80例慢性阻塞性肺疾病急性加重期患者,用随机数字表法将80例患者分为两组,各40例。对照组采用常规西药疗法治疗,观察组在对照组的基础上增加使用清肺降逆汤治疗,对比两种不同给药方案对临床疗效、肺功能、炎性因子、临床症状改善、用药安全性产生影响的异同。结果通过对比临床总体疗效,观察组的总有效率为95.0%,较对照组的80.0%相比,差异有统计学意义(χ^(2)=4.114,P=0.043 <0.05);治疗后与治疗前相比两组的临床症状均改善,而观察组治疗后的临床症状评分均显著小于对照组,差异有统计学意义(P <0.05);治疗后两组患者的肺功能指标和炎性因子水平均明显低于治疗前,且观察组治疗后的肺功能指标和炎性因子水平均显著低于对照组,差异有统计学意义(P<0.05);经对比两种治疗方案的安全性,发现观察组与对照组患者治疗期间的不良反应发生率相比,差异无统计学意义(P> 0.05)。结论对于慢性阻塞性肺疾病急性加重期患者,临床上采用清肺降逆汤治疗兼具有效性和安全性,更有利于改善患者的临床症状,同时可改善患者的肺功能。

Objective To study the clinical efficacy of Qingfei Jiangni decoction in the treatment of acute exacerbation of chronic obstructive pulmonary disease.Methods Now the research object was 80 patients with acute exacerbation of chronic obstructive pulmonary disease in our hospital from May 2019 to July 2020.80 patients were randomly divided into two groups,40 cases in each group.The control group was treated with conventional western medicine therapy,and the observation group was treated with Qingfei Jiangni decoction on the basis of the control group.The differences of clinical efficacy,lung function,inflammatory factor levels and improvement of clinical symptoms and medication safety of the two different administration schemes were compared.Results By comparing the overall clinical efficacy,the total effective rate of the observation group was 95.0%,which was significantly higher than 80.0%of the control group(χ^(2)=4.114,P=0.043<0.05);after treatment,compared with before treatment,the clinical symptoms of the two groups were improved,and the clinical symptom scores of the observation group were significantly lower than those of the control group,with significant difference(P<0.05);after treatment,the lung function and inflammatory factor levels indexes of the two groups were significantly lower than before treatment,and the lung function and inflammatory factor levels index of the observation group after treatment was significantly lower than that of the control group,the difference was statistically significant(P<0.05);by comparing the safety of the two treatment schemes,it was found that the incidence of adverse reactions between the observation group and the control group during treatment,the difference was not statistically significant(P>0.05).Conclusion For patients with acute exacerbation of chronic obstructive pulmonary disease,clinical use of Qingfei Jiangni decoction has both effectiveness and safety,which is more conducive to improving the clinical symptoms of patients,and can improve the lung function of patients.