干扰素治疗生殖器疱疹的用药策略

Interferon in the Treatment of Genital Herpes

生殖器疱疹(genital herpes, GH)是由单纯疱疹病毒感染引起的一种常见的性传播疾病,我国生殖器疱疹病人众多,且发病率逐年增加。此病易复发,严重影响病人的身心健康,因此,迫切需要寻找出有效安全的治疗方法。生殖器疱疹的治疗目的旨在缓解临床症状、降低复发率。目前国内外治疗指南均推荐阿昔洛韦、伐昔洛韦、泛昔洛韦为治疗GH的一线药物,但此类抗病毒药物在应用一段时间后易产生耐药性,因此有必要寻找出其他药物联合治疗,从而增强疗效,减少复发率。干扰素具有广谱抗病毒、抑制细胞增殖和调节免疫的功能。重组人干扰素α是临床上常用于联合阿昔洛韦等治疗生殖器疱疹的药物,其疗效显著,治疗方法多样,包括肌肉注射、局部封闭和外用,可根据病情及患者的耐受程度选择治疗方案。

Genital herpes(GH) is a common sexually transmitted disease caused by herpes simplex virus.It is prone to frequent relapses with serious consequences on physical and mental well-being of the patients.Therefore, effective and safe treatment is urgently desired.Ideal treatment objectives include clinical symptomatic relief and reduction in recurrence rate.Current treatment guidelines recommend acyclovir, valaciclovir and famiclovir as first-line drugs all over the world.However, resistance is common with long term usage.It is necessary to find other combined treatment methods in order to enhance the curative effect and reduce the recurrence rate.Interferon has broad-spectrum antiviral functions, inhibit cell proliferation, and regulate immunity.Recombinant human interferon α commonly used in combination with acyclovir and other drugs in the treatment of GH.It has remarkable curative effect and various treatment strategies, such as intramuscular injection, intradermal injection and external application.The treatment strategy can be selected according to the condition and tolerance of patients.