摘要
在手性磷酸的作用下,实现了异噁唑啉酮和对苯醌单亚胺的不对称芳基化反应,以高收率和高对映选择性构建了4-芳基异噁唑啉酮衍生物。对其中一个产物进行单晶培养,确定了绝对构型。
A highly enantioselective arylation of isoxazolones with quinone monoimines has been established under a chiral phosphoric acid.A range of arylation products containing an all-carbon quaternary stereocenter were prepared with good yields and moderate to good enantioselectives.The absolute configuration of a product was unambiguously confirmed by single-crystal X-ray diffraction.
作者
张家燕
黄敏
张晓梅
ZHANG Jia-yan;HUANG Min;ZHANG Xiao-mei(Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences,Chengdu 610041,China;University of Chinese Academy of Sciences,Beijing 100049,China)
出处
《合成化学》
CAS
2022年第1期47-57,共11页
Chinese Journal of Synthetic Chemistry
基金
国家自然科学基金资助项目(21672208)。
关键词
手性磷酸
异噁唑啉酮
对苯醌单亚胺
不对称芳基化
合成
绝对构型
chiral phosphoric acid
Isoxazolones
quinone monoimines
asymmetric arylation
synthesis
absolute configuration
