摘要
以N-(甲氧甲基)-N-(三甲基硅甲基)苄胺和马来酸二甲酯为原料通过环加成、氢化铝锂还原、TsOH催化脱水、氢氧化钯/碳催化氢化脱苄基四步反应,设计并合成了一种含氮、氧的杂环化合物——顺式六氢-^(1)H-呋喃并[3,4-C]吡咯,其结构经^(1)H NMR,^(13)C NMR和MS(ESI)表征。
A nitrogen-containing and oxygen-containing heterocyclic compound, cis -hexahydro-^(1)H -furo[3,4- C ]pyrrole was designed and synthesized. It was synthesized by a four-step reaction, using N -(methoxymethyl)- N -(trimethylsilylmethyl)benzylamine and dimethyl maleate as raw materials through cycloaddition, lithium aluminum hydride reduction, TsOH catalyzed dehydration, palladium hydroxide/carbon catalyzed hydrogenation debenzylation reaction, The structure of the final product was confirmed by ^(1)H NMR, ^(13)C NMR and MS(ESI).
作者
张晨曦
刘娟
任金娜
薛志勇
ZHANG Chen-xi;LIU Juan;REN Jin-na;XUE Zhi-yong(College of Chemistry and Chemical Engineering,Wuhan Textile University,Wuhan 430073,China)
出处
《合成化学》
CAS
2022年第1期63-66,共4页
Chinese Journal of Synthetic Chemistry
基金
国家自然科学基金资助项目(21602163)
湖北省自然科学基金资助项目(2016CFB261)
湖北省教育厅中青年人才项目(Q20161607)
生物质纤维与生态染整湖北省重点实验室开放课题(STRZ201907)。
关键词
氮杂环化合物
氧杂环化合物
环加成反应
呋喃
吡咯
合成
nitrogen-containing heterocyclic compound
oxygen-containing heterocyclic compound
cycloaddition reaction
furan
pyrrole
synthesis
