巨噬细胞功能障碍影响糖尿病创面愈合的研究进展

Effect of macrophage dysfunction on diabetic wound healing:a review of research progress

巨噬细胞在创面愈合的炎症、增殖和修复重建阶段中均扮演了重要角色,其功能异常可能导致创面的迁延不愈。糖尿病创面作为最常见的慢性创面类型之一,其长期高糖微环境、异常的代谢环境等常常导致巨噬细胞的极化异常,细胞因子的异常分泌和巨噬细胞吞噬清除功能异常,引起创面持续氧化应激和炎症反应,炎症期明显延长而增殖期及重建期延迟或异常,从而导致软组织创面延迟愈合或不愈合。糖尿病创面迁延不愈给患者家庭和社会造成了巨大的经济负担。本综述简要回顾近期国内外相关研究进展,总结分析巨噬细胞极化功能、分泌功能和吞噬功能障碍在影响糖尿病创面愈合过程中的作用。

Macrophages play a crucial role in inflammatory,proliferative and reconstructive phases in wound healing.A dysfunction of macrophage could lead to a delay of healing.As the most common type of chronic wounds,the diabetic wound may ultimately result in a delayed or failed wound healing due to a high glucose microenvironment and abnormal metabolic environment.Such abnormal metabolic environment may lead to the aberrant macrophage polarization,abnormal secretion of cytokines and aberrant phagocytic function hence cause prolonged inflammation with excessive oxidative stress reaction.As the consequence,the inflammatory phase in diabetic wound is lengthy while the proliferative and reconstructive phases are usually delayed.The diabetic wound may result in enormous financial burden to patients,the healthcare and the society.This study briefly reviewed the recent research progresses at home and abroad,and analysed and summarized the roles of the dysfunction of macrophage polarization,secretion and phagocytosis in the process of diabetic wound healing.