肿瘤相关髓系细胞在多发性骨髓瘤中的研究进展

Progress of tumor-associated myeloid cells in multiple myeloma

多发性骨髓瘤(MM)是一种血液系统恶性肿瘤,目前针对MM的治疗方案层出不穷,但仍不可治愈。除耐药外,MM不能治愈的另一个重要原因是肿瘤细胞与骨髓免疫微环境之间的相互作用所产生的免疫抑制,导致机体不能清除残留的肿瘤细胞。肿瘤相关髓系细胞(TAMC)是MM免疫抑制微环境的重要组成部分,在MM的免疫逃逸中发挥着极其重要的作用,同时也是限制免疫治疗效果提高的重要原因,成为了治疗MM的潜在靶点。文章系统阐述TAMC的组成及其在MM免疫微环境中作用机制的最新研究进展。

Multiple myeloma(MM)is a kind of hematologic malignancy.Although there are lots of therapies for MM,it is still incurable.Except for the drug-resistance,another important reason for the incurability is the immunosuppressive effect derived from interactions between tumor cells and the bone marrow microenvironment,which makes our body cannot clear resident tumor cells completely.As a vital part in the immunosuppressive microenvironment,tumor-associated myeloid cells(TAMC)play an extremely significant role in the immune escape of MM and become the reason for limiting the effectiveness of immunotherapy,furthermore,TAMC have become potential targets for the treatment of MM.This article reviews the composition and the latest progress of the mechanisms of TAMC in the immune microenvironment of MM.