6-溴-2-甲氧基-3-氨基吡啶的合成

Synthesis of 6-Bromo-2-methoxypyridin-3-amine

以2,6-二溴-3-氨基吡啶为起始原料,经过亲核取代反应制备了重要的医药中间体6-溴-2-甲氧基-3-氨基吡啶。目标化合物的收率为80.1%。由核磁共振氢、碳谱以及质谱对化合物结构进行了表征确证。该制备方法具有原料易得、反应条件温和、收率高、易于纯化的优点,为6-溴-2-甲氧基-3-氨基吡啶的工业化生产提供了新的途径。

6-Bromo-2-methoxypyridin-3-amine,an important pharmaceutical intermediate,was prepared from 3-amino-2,6-dibromopyridine through nucleophilic substitution reaction.The total yield of this target compound was of 80.1%.The product was characterized using ^(1)H NMR and ^(13)C NMR and LC-MS.This method had the advantages of easy availability of raw materials,mild reaction conditions,high yield and easy purification.It provided a new way for 6-bromo-2-methoxypyridin-3-amine magnification feeding and industrial production.