双相障碍患者氧化应激反应与冲动攻击行为的相关性

Correlation between oxidative stress response and impulsive aggressive behavior in patients with bipolar disorder

目的:探讨双相障碍患者的氧化应激反应与冲动攻击行为的关系。方法:回顾分析2017年1月至2020年3月本院治疗的85例双相障碍患者资料,根据是否有冲动攻击行为分为有攻击行为组(n=29)和无攻击行为组(n=56);比较两组基线资料与氧化应激反应指标[超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、血清总胆红素(TBIL)、血清白蛋白(Alb)],Logistic回归分析双相障碍患者冲动攻击行为的影响因素。结果:有攻击行为组血清SOD、CAT、Alb、TBIL水平均低于无攻击行为组,差异有统计学意义(P均<0.01)。经单项Logistic回归分析后建立多元回归模型,结果显示,血清SOD、CAT、Alb、TBIL水平低表达是双相障碍患者冲动攻击行为的影响因素,其中TBIL带来的影响最为显著,可能作为独立危险因素(P<0.05或P<0.01)。结论:氧化应激指标Alb、TBIL、SOD与CAT低水平与双相障碍患者攻击行为有关。

Objective:To explore the oxidative stress response and impulsive aggressive behavior in patients with bipolar disorder.Method:The data of 85 bipolar disorder patients treated in our hospital from January 2017 to March 2020 were respectively analyzed.According to whether there was impulsive aggressive behavior,they were divided into aggressive behavior group(n=29)and non-aggressive behavior group(n=56).The baseline data and the oxidative stress response indicators[superoxide dismutase(SOD),catalase(CAT),serum total bilirubin(TBIL),serum albumin(Alb)]of the two groups were compared,and the influencing factors of impulsive aggressive behavior in patients with bipolar disorder were analyzed by Logistic regression.Results:The serum SOD,CAT,Alb and TBIL levels of the aggressive behavior group were lower than those of the non-aggressive behavior group,and the differences were statistically significant(all P<0.01).After a single Logistic regression analysis,a multiple regression model was established,the results showed that the low expression of serum SOD,CAT,Alb and TBIL were all influencing factors of impulsive aggressive behavior in patients with bipolar disorder.Among them,TBIL had the most significant impact,which might be used as an independent risk factor(P<0.05 or P<0.01).Conclusion:Low levels of oxidative stress indexes Alb,TBIL,SOD and CAT are associated with aggressive behavior in patients with bipolar disorder.