慢性酒依赖患者的失匹配负波改变与其人格特征的关系

Changes of mismatch negativity and its relation with personality characters in patients with chronic alcohol dependence

目的:探讨慢性酒依赖(CAD)患者失匹配负波(MMN)改变与其人格特征的关系。方法:采用改良的艾森克人格问卷(EPQ-R)对33例CAD患者(CAD组)和33名健康对照志愿者(对照组)进行评估,同时进行事件相关电位(ERP)检测,分析CAD患者MMN指标与其人格特征的关系。结果:CAD组EPQ-R中神经质(N)、精神质(P)和掩饰性(L)维度评分显著高于对照组(P<0.05或P<0.01);ERP各通道MMN潜伏期显著延长(P<0.05或P<0.01)。相关分析显示,CAD患者MMN指标与其人口学资料及人格特征无相关性。结论:CAD患者具有神经质、精神质的人格特征,其MMN潜伏期延长,但MMN改变与其人格特征无相关性。

Objective:To explore the changes of mismatch negativity and its relation with personality characters in patients with chronic alcohol dependence.Method:Modified Eysenck's Personality Questionnaire was administered in 33 chronic alcoholics(CAD group)and 33 healthy volunteer controls(control group).Event related potentials were detected and the relation of mismatch negativity and personality characters in chronic alcoholics was analyzed.Results:Compared to the control group,the scores of neuroticism(N),psychoticism(P),lie(L)were significantly higher in the CAD group(P<0.05 or P<0.01).MMN peak latency was significantly delayed in chronic alcoholics(P<0.05 or P<0.01).Correlation analysis showed that there was no correlation between MMN index and demographic data and personality characteristics in the CAD patients.Conclusion:CAD patients have neurotic and psychotic personality characteristics,the MMN latency is delayed,but there are no correlation between the change of MMN and its personality characteristics.