DDRs对免疫细胞调控机制的研究进展

Research progress of regulatory mechanism of DDRs on immune cells

盘状结构域受体(DDRs)是受体酪氨酸激酶(RTKs)超家族的重要成员,由DDR1和DDR2组成。胶原蛋白与DDRs特异性结合可诱导其酪氨酸磷酸化,从而引起下游细胞信号的转导。目前,研究表明DDRs在树突状细胞、巨噬细胞、小胶质细胞、中性粒细胞、T淋巴细胞中均有表达,并通过NF-κB、p38 MAPK、JNK、ERK等信号通路参与免疫细胞的黏附、迁移和分泌,从而调节炎症、纤维化、肿瘤等多种疾病的发生发展。本文将围绕DDRs对免疫细胞调控机制的研究进展进行概述,并进一步探讨DDRs通过免疫细胞在各种疾病中的调节作用,以期为针对DDRs靶点的生物医学治疗和新型药物研发提供一定的参考价值。

Discoidin domain receptors(DDRs)is an important member of the receptor tyrosine kinases(RTKs)superfamily,which is consisted of DDR1 and DDR2. The specific binding of collagen to DDRs can induce its tyrosine phosphorylation,which leads to signal transduction of downstream cells. At present,studies have shown that DDRs is expressed in dendritic cells,macrophages,microglia,neutrophils and T lymphocytes,and is involved in the adhesion,migration and secretion of immune cells through NF-κB,p38 MAPK,JNK,ERK and other signal pathways,which regulates the occurrence and development of various diseases such as inflammation,fibrosis,tumor and so on. This article will summarize the research progress of DDRs on the regulatory mechanism of immune cells,and further explore the regulatory role of DDRs in various diseases through immune cells,in order to provide reference value for biomedical therapy and new drug development of DDRs targets.