原发性干燥综合征生物标志物的研究进展

Research progress of biomarkers in primary Sj?gren’s syndrome

目前原发性干燥综合征(pSS)诊断仍然依赖于侵入性小涎腺活检手术,常导致其早期诊断异常艰难,因此筛选特定生物标志物可能对pSS诊断和个体化治疗极为有益。本文回顾传统标志物及与B细胞活化和表观遗传相关的新标志物,并综述组学标志物研究进展。尽管生物标志物前景较好,但其可靠性仍需扩大样本量进行验证。

Diagnosis of primary Sj?gren’s syndrome(pSS)still relied on invasive small salivary gland biopsy at present,which often lead to early diagnosis of disease was very difficult. Therefore,screening out specific biomarkers might be extremely useful for diagnosis and individualized treatment of pSS. This paper reviewed traditional markers,new markers related to B cell activation and epigenetics,and progress of omics markers. Although prospects for biomarkers were promising,their reliability still need to be verified by large sample studies.