周细胞在肾间质纤维化中的研究进展

Research advances of pericytes in renal interstitial fibrosis

周细胞是与内皮细胞接触并部分包埋于血管基底膜的间充质细胞。周细胞具有分化能力,其表面标志物根据不同组织、不同发育阶段、不同病理生理环境而发生变化。研究表明,周细胞是肾脏肌成纤维细胞的主要来源,多种信号通路参与了周细胞/成纤维细胞转分化为肌成纤维细胞的过程。本文综述了周细胞在肾间质纤维化发病机制中的研究进展,提出了周细胞作为靶点治疗肾间质纤维化的价值。

Pericytes are mesenchymal cells in contact with endothelial cells and partially embed⁃ded in the basement membrane of blood vessels.Pericytes possess the capability of differentiating and their surface markers change according to different tissues,various developmental stages and diverse pathophysiological environments.Numerous studies have demonstrated that pericytes are a major source of kidney myofibroblasts and multiple signal pathways are involved in the process of pericytes/fibroblasts transdifferentiation into myofibroblasts.Pericyte-endothelial cell interaction also plays an important role in the development of renal fibrosis.This review summarized the latest advances of pericytes in the patho⁃genesis of renal intestitial fibrosis and targeted therapy for pericytes may be an effective anti-kidney fibro⁃sis strategy.