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苯海拉明致急性肾小管损伤1例并文献复习 被引量:1

Acute renal tubular injury caused by diphenhydramine:one case report with a literature review
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摘要 病例资料患者,男,31岁,其母亲代诉2个月余前,因欲自杀而一次服下盐酸苯海拉明约200片(5000 mg)。家人发现时,患者表现为双眼上翻,口唇发绀,四肢抖动,二便失禁,间断抽搐,伴恶心,呕吐数次,为非喷射性呕吐胃内容物,逐渐意识丧失直至昏迷。家人立即送至当地医院,查血常规。
作者 何娟 王妍 王頔 王汉民 He Juan;Wang Yan;Wang Di;Wang Han-min(Department of Nephrology,First Municipal Hospital,Xi’an 710002,China;Department of Nephrol-ogy,Affiliated Xijing Hospital,Fourth Military Medical University,Xi’an 710032,China)
出处 《临床肾脏病杂志》 2022年第1期82-85,共4页 Journal Of Clinical Nephrology
基金 国家自然科学基金青年科学基金(81700676)
关键词 苯海拉明 中毒 血液净化 急性肾小管损伤 Diphenhydramine Poisoning Blood purification Acute tubular injury
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  • 1马晓伟,邵明立.中国医师药师临床用药指南[M].重庆:重庆出版社,2009:950-951.
  • 2Vearrier D, Curtis JA. Case files of the medical toxicology fellowship at Drexel University. Rhabdomyolysis and compartment syndrome following acute diphenhydramine overdose [ J ]. J Med Toxicol, 2011, 7 (3) : 213 -219.
  • 3Wang GS, Monte A, Bagdure D, et al. Hepatic failure despite early acetylcysteine following large acetaminophen - diphenhydramine overdose [J]. Pediatrics, 2011, 127 (4): e1077 - e1080.
  • 4Sype JW, Khan IA. Prolonged QT interval with markedly abnormal ventricular repolarization in diphenhydramine overdose [ J ]. Int J Cardiol, 2005, 99 (2): 333-335.
  • 5Sanaei- Zadeh H. The first published case of a pediatric diphenhydramine overdose whose electrocardiogram shows terminal 40 - millisecond frontal- plane QRS axis deviation [ J ]. Pediatr Emerg Care, 2012, 28 (7): 730.
  • 6Radovanovic D, Meier PJ, Guirguis M, et al. Dose - dependent toxicity of diphenhydramine overdose [ J ]. Hum Exp Toxicol, 2000, 19 (9): 489-495.

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