银杏叶注射液联合曲美他嗪治疗慢性充血性心力衰竭的临床观察

Clinical Efficacy of Ginkgo Biloba Injection Combined with Trimetazidine in the Treatment of Chronic Congestive Heart Failure

目的探讨银杏叶注射液联合曲美他嗪治疗慢性充血性心力衰竭的临床疗效。方法选取2018年2月—2020年6月期间南京医科大学附属脑科医院心血管内科收治慢性充血性心力衰患者100例,按随机数字表法分为对照组和治疗组,每组各50例。两组患者均给予强心、扩血管、利尿等对症治疗,在此基础上对照组给予盐酸曲美他嗪缓释片治疗,治疗组在对照组基础上加用银杏叶注射液治疗。治疗14 d后,观察其比较两组患者临床疗效、中医证候症状积分、心功能相关指标(B型利钠肽前体、心肌肌钙蛋白I、左室射血分数、6 min步行距离及不良反应发生情况)。结果治疗后观察组总有效率94.00%(47/50),对照组总有效率76.00%(38/50),两组比较,差异有统计学意义(P<0.05)。治疗后两组患者中医症状积分均较治疗前明显降低,差异有统计学意义(P<0.05);且治疗组中医症状积分较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者B型利钠肽前体、心肌肌钙蛋白I指标均较治疗前降低,左室射血分数、6 min步行距离指标均较治疗前升高,差异有统计学意义(P<0.05);且治疗组B型利钠肽前体、心肌肌钙蛋白I较对照组明显降低,左室射血分数、6 min步行距离较对照组明显升高,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论银杏叶注射液联合曲美他嗪治疗慢性充血性心力衰竭的疗效显著,能明显改善患者临床症状,可能与逆转心脏重塑,提高患者运动功能有关,且安全性可靠。

Objective To investigate the clinical effect of Ginkgo biloba injection combined with trimetazidine in the treatment of chronic congestive heart failure.Methods A total of 100 patients with chronic congestive heart failure admitted to our hospital from February 2018 to June 2020 were selected and divided into a control group and a treatment group according to a random number table,with 50 cases in each group.Both groups of patients were given symptomatic treatments such as cardiotonic,vasodilation,and diuresis.On this basis,the control group was given trimetazidine hydrochloride sustained-release tablets,and the treatment group was given Ginkgo biloba injection on the basis of the control group.After 14 days of treatment,the clinical efficacy,TCM syndrome symptom score,cardiac function related indexes(NT-ProBNP,LVEF,6 MWD)and adverse reactions were analyzed and compared.Results After treatment,the total effective rate of the observation group was 94.00%(47/50),and the total effective rate of the control group was 76.00%(38/50).The difference between the two groups was statistically significant(P<0.05).After treatment The TCM symptom scores of the two groups were significantly lower than those before treatment,and the difference was statistically significant(P<0.05);and the TCM symptom scores of the treatment group were significantly lower than those of the control group,and the difference was statistically significant(P<0.05).In the group of patients,B-type natriuretic peptide precursor and cardiac troponin I were lower than before treatment,and the left ventricular ejection fraction and 6-min walking distance were higher than before treatment,and the difference was statistically significant(P<0.05).And the treatment group B-type natriuretic peptide precursor and cardiac troponin I were significantly lower than those of the control group,and the left ventricular ejection fraction and 6-min walking distance were significantly higher than those of the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups of patients(P>0.05).Conclusion Ginkgo biloba injection combined with TMZcan significantly improve the clinical symptoms of patients,which may be related to reversing cardiac remodeling and improving motor function,and it is safe and reliable.