无创正压通气联合药物干预在呼吸衰竭急诊治疗中的疗效及对肺功能的影响

Effect of noninvasive positive pressure ventilation combined with drug intervention in emergency treatment of respiratory failure and its influence on pulmonary function

目的:研究无创正压通气联合药物干预在呼吸衰竭急诊治疗中的疗效及对肺功能的影响。方法:回顾性分析84例呼吸衰竭患者的临床资料,所有患者于2019年1月~2020年6月期间接受治疗,按照治疗方案的不同将其分为对照组与观察组,每组有42例患者;两组患者给予常规治疗与无创正压通气,观察组在此基础上给予纳洛酮治疗;对比分析两组治疗前后的病情严重程度、血气分析指标、肺功能指标以及整体治疗效果。结果:治疗后5 d,观察组动脉血氧分压(PaO_(2))、血氧饱和度(SaO_(2))均较对照组相应数值高,其动脉二氧化碳分压(PaCO_(2))较对照组相应数值低,差异有统计学意义(P<0.05);观察组1秒用力呼气容积(FEV1)、用力肺活量(FVC)及1秒用力呼吸容积与肺活量比值(FEV1/FVC)均较对照组相应数值高,差异有统计学意义(P<0.05);观察组急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)低于对照组,差异有统计学意义(P<0.05);观察组总有效率(95.24%)高于对照组(80.95%),差异有统计学意义(P<0.05)。结论:在呼吸衰竭急诊治疗中应用无创正压通气联合纳洛酮干预可以取得良好的治疗效果,有助于调节患者的血气分析指标,使其恢复正常水平,并改善患者的临床症状与肺功能,促进其病情好转。

Objective To study the effect of noninvasive positive pressure ventilation combined with drug intervention in the emergency treatment of respiratory failure and its influence on lung function.Method The clinical data of 84 patients with respiratory failure were retrospectively analyzed.All patients received treatment from January 2019 to June 2020.According to the different treatment schemes,they were divided into control group and observation group,with 42 patients in each group.The two groups were given conventional treatment and noninvasive positive pressure ventilation,and the observation group was given naloxone on this basis.The severity of the disease,blood gas analysis index,lung function index and the overall treatment effect before and after treatment of the two groups was compared and analyzed.Results On the 5 th day after treatment,PaO_(2)and SaO_(2)of the observation group were higher than those of the control group,and PaCO_(2)of the observation group was lower than those of the control group(P<0.05);FEV1,FVC and FEV1/FVC of the observation group were higher than those of the control group(P<0.05);the APACHEⅡof the observation group was lower than that of the control group(P<0.05);the total effective rate of the observation group(95.24%)was higher than that of the control group(80.95%)(P<0.05).Conclusion The application of noninvasive positive pressure ventilation combined with naloxone intervention in the emergency treatment of respiratory failure can achieve good therapeutic effect,help to regulate the blood gas analysis indexes of patients,make them return to normal level,improve the clinical symptoms and lung function of patients,and promote the improvement of their condition.