妊娠期妇女甲状腺功能检测指标的临床应用意义

Clinical significance of thyroid function in pregnant women

目的:探讨分析甲状腺功能检测指标在妊娠期妇女的临床应用意义。方法:抽取接受血清甲状腺功能检测的60例妊娠期妇女作为研究组,抽取同期接受甲状腺功能检测的60例育龄非妊娠妇女作为对照组,两组受检者均进行促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))、甲状腺过氧化物酶抗体(TPOAB)检测,比较两组各甲状腺功能检测指标水平、甲状腺功能异常疾病发生情况。结果:研究组孕早期TSH与TPOAB水平显著降低且低于对照组,孕中期后逐渐增加,FT_(4)与T_(4)显著增加高于对照组,且孕中期后呈下降趋势变化,差异有统计学意义(P<0.05);研究组甲状腺功能功能减退(13.33%)、甲状腺功能亢进(16.67%)、甲状腺炎发病率(13.33%)均高于对照组(3.33%、3.33%、1.67%),甲状腺相关疾病患病率(43.33%)显著高于对照组(8.33%),差异有统计学意义(P<0.05)。结论:甲状腺相关疾病是孕期女性常见并发症,发生风险较高,需引起临床重视与排查,孕期甲状腺功能指标检测能较好地反映其疾病情况,加强甲状腺激素指标的检查有助于及早发现甲状腺疾病,对优生优育及孕期女性健康具有重要价值。

Objective To analyze the clinical use of thyroid function test indicators the occurrence of abnormal thyroid dysfunction.in women during pregnancy.Method 60 cases of pregnant women who received serum thyroid function testing were selected as the research group,and 60 cases of non-pregnant women of childbearing age who received thyroid function testing during the same period were selected as the control group.Two groups All subjects were tested for thyroid hormone(TSH),free triiodothyronine(FT_(3)),free thyroxine(FT_(4)),and thyroid peroxidase antibody(TPOAB).The levels of thyroid function test indicators and the occurrence of abnormal thyroid dysfunction in the two groups were compared.Results The levels of TSH and TPOAB in the study group were significantly lower in the first trimester and lower than the control group,and gradually increased after the second trimester.FT_(4) and T_(4) increased significantly higher than the control group,and showed a downward trend after the second trimester,the difference was statistically significant(P<0.05);The incidence of hypothyroidism(13.33%),hyperthyroidism(16.67%),and thyroiditis(13.33%)in study group were all higher than those of the control group(3.33%、3.33%、1.67%),and the prevalence of thyroid-related diseases(43.33%)was significant higher than the control group(8.33%),the difference was statistically significant(P<0.05).Conclusion Thyroid-related diseases are a common complication of women during pregnancy,and the risk of occurrence is high.It needs clinical attention and investigation.The detection of thyroid function indicators during pregnancy can better reflect their disease conditions.Strengthening the examination of thyroid hormone indicators can help detect thyroid diseases early.It has important value for prenatal and postnatal care and women's health during pregnancy.