氯吡格雷联合依达拉奉治疗急性脑梗死的疗效评价

Evaluation on the efficacy of clopidogrel combined with edaravone in the treatment of acute cerebral infarction

目的探讨氯吡格雷联合依达拉奉治疗急性脑梗死患者的临床疗效。方法186例急性脑梗死患者,根据治疗方法不同分为对照组(88例)和观察组(98例)。对照组应用氯吡格雷治疗,观察组应用氯吡格雷联合依达拉奉治疗。对比两组患者的治疗效果及治疗前后神经功能缺损评分、凝血功能指标。结果观察组治疗总有效率为95.9%,高于对照组的84.1%,差异有统计学意义(P<0.05)。治疗前,两组神经功能缺损评分对比差异无统计学意义(P>0.05);治疗后,观察组神经功能缺损评分(8.76±1.35)分低于对照组的(14.73±2.12)分,差异有统计学意义(P<0.05)。治疗前,两组凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)及D-二聚体水平对比差异无统计学意义(P>0.05);治疗后,观察组PT、APTT、FIB、D-二聚体水平分别为(13.45±1.01)s、(28.01±1.72)s、(2.43±0.21)g/l、(0.31±0.07)mg/l,优于对照组的(12.39±1.02)s、(25.73±1.89)s、(2.80±0.42)g/L、(0.37±0.09)mg/L,差异有统计学意义(P<0.05)。结论氯吡雷联合依达拉奉治疗急性脑梗死疗效优于单纯应用氯吡格雷治疗,能有效改善患者凝血功能,利于神经功能恢复,对促进患者康复作用显著。

Objective To discuss the clinical efficacy of clopidogrel combined with edaravone in the treatment of acute cerebral infarction.Methods A total of 186 patients with acute cerebral infarction were divided into control group(88 cases)and observation group(98 cases)according to different treatment methods.The control group was treated with clopidogrel,and the observation group was treated with clopidogrel and edaravone.The therapeutic effects,neurological deficits score and coagulation function indexes before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.9%,which was higher than 84.1%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in neurological deficits score between the two groups(P>0.05).After treatment,the neurological deficit score(8.76±1.35)points of the observation group was lower than(14.73±2.12)points of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the levels of prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB)and D-dimer between the two groups(P>0.05).After treatment,the levels of PT,APTT,FIB and D-dimer in the observation group were(13.45±1.01)s,(28.01±1.72)s,(2.43±0.21)g/L,and(0.31±0.07)mg/L,which were better than(12.39±1.02)s,(25.73±1.89)s,(2.80±0.42)g/L,and(0.37±0.09)mg/L in the control group,and the difference was statistically significant(P<0.05).Conclusion Clopidogrel in combination with edaravone has better efficacy in the treatment of acute cerebral infarction than that of clopidogrel alone,which can effectively improve the coagulation function of patients,and is conducive to the recovery of neurological function,and has a significant effect on promoting the rehabilitation of patients.