灯盏花素配合激素治疗肾病综合征临床疗效观察

Clinical efficacy of breviscapine combined with hormone in the treatment of nephrotic syndrome

目的分析灯盏花素配合激素治疗肾病综合征的临床疗效。方法50例肾病综合征患者,根据治疗方法不同分为观察组与对照组,各25例。对照组仅采用灯盏花素治疗,观察组采用灯盏花素基础上配合激素治疗。比较两组患者临床疗效、病情缓解时间及临床指标[白蛋白(ALB)、肌酐(Scr)、血清总胆固醇(TC)、24 h尿蛋白定量、甘油三酯(TG)]。结果观察组治疗总有效率96.00%高于对照组的68.00%,差异有统计学意义(P<0.05)。观察组病情缓解时间为(25.89±11.05)h,对照组病情缓解时间为(31.46±12.94)h;观察组病情缓解时间短于对照组,差异有统计学意义(P<0.05)。治疗前,两组TG、Scr、24 h尿蛋白定量、TC及ALB水平比较,差异无统计学意义(P>0.05);治疗后,两组TG、Scr、24 h尿蛋白定量、TC及ALB水平均优于治疗前,且观察组优于对照组,差异有统计学意义(P<0.05)。结论使用灯盏花素联合激素治疗肾病综合征可缓解患者的临床症状,改善各临床指标,具有临床推广价值。

Objective To analyze the clinical efficacy of breviscapine combined with hormone in the treatment of nephrotic syndrome.Methods A total of 50 patients with nephrotic syndrome were divided into observation group and control group according to different treatment methods,with 25 cases in each group.The control group was treated with breviscapine only,and the observation group was treated with breviscapine in combination with hormone therapy.Patients in both groups were compared in terms of clinical efficacy,remission time and clinical indicators[albumin(ALB),serum creatinine(Scr),total cholesterol(TC),24-h urinary total protein,triglycerides(TG)].Results The total effective rate of treatment 96.00%in the observation group was higher than 68.00%in the control group,and the difference was statistically significant(P<0.05).The remission time of the observation group was(25.89±11.05)h,and the remission time of the control group was(31.46±12.94)h;the remission time of the observation group was shorter than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference between the two groups of TG,Scr,24-h urinary total protein,TC and ALB levels(P>0.05).After treatment,TG,Scr,24-h urinary total protein,TC and ALB levels of both groups were better than those before treatment,and the observation group was better than the control group.All the differences were statistically significant(P<0.05).Conclusion Combination of breviscapine and hormone can alleviate the clinical symptoms of patients,improve various clinical indicators,and has the value of clinical promotion.