经皮经肝胆管穿刺引流术对急性梗阻性化脓性胆管炎的CPR及ALT影响

Effects of percutaneous transhepatic biliary drainage on CPR and ALT in acute obstructive suppurative cholangitis

目的探究超声引导下经皮经肝胆管穿刺引流术(PTCD)对急性梗阻性化脓性胆管炎C反应蛋白(CPR)、丙氨酸转移酶(ALT)的影响。方法回顾性分析2016年9月至2018年5月本院收治的114例急性梗阻性化脓性胆管炎患者的临床资料,按照治疗方法分为两组,各57例。对照组采取经内镜逆行胰胆管造影(ERCP)治疗,观察组采用PTCD治疗,比较两组CRP、肿瘤坏死因子-α(TNF-α)、ALT、天冬氨酸基转移酶(AST)水平、症状缓解时间以及住院时间。结果术后3 d,观察组CRP、TNF-α、ALT、AST水平均明显低于对照组(P<0.05);观察组寒战缓解时间、高热缓解时间、腹痛缓解时间以及住院时间均明显短于对照组(P<0.05)。结论 PTCD能缓解急性梗阻性化脓性胆管炎患者的炎症反应,并改善临床症状,缩短住院时间。

Objective To investigate the effect of ultrasound-guided percutaneous transhepatic biliary drainage(PTCD) on C-reactive protein(CPR) and alanine transferase(ALT) in acute obstructive suppurative cholangitis. Methods The clinical data of 114 patients with acute obstructive suppurative cholangitis treated in our hospital from September 2016 to May 2018 were analyzed retrospectively. According to the treatment methods,they were divided into two groups, with 57 cases in each group. The control group was treated with endoscopic retrograde cholangiopancreatography(ERCP), and the observation group was treated with PTCD, CRP and tumor necrosis factor-α(TNF-α), ALT, aspartate transferase(AST) levels, symptom relief time and hospital stay were compared between the two groups. Results 3 d after operation, the CRP, TNF-α, ALT, AST level in the observation group were significantly lower than the control group(P<0.05), the shivering relief time, high fever relief time, abdominal pain relief time and hospital stay in the observation group were significantly shorter than those in the control group(P<0.05). Conclusion PTCD can alleviate the inflammatory reaction of patients with acute obstructive suppurative cholangitis, improve clinical symptoms, and shorten the length of hospital stay.