血府逐瘀汤对股骨颈骨折患者血清IGF-1、VEGF、BMP-2水平及预后的影响

Effect of Xuefu Zhuyu Decoction on Serum IGF-1,VEGF,BMP-2 Levels and Prognosis of Invalids with Femoral Neck Fracture

目的探究血府逐瘀汤对股骨颈骨折患者血清IGF-1、VEGF、BMP-2水平及预后的影响。方法研究对象选取2019年12月—2020年9月在青岛市城阳古镇正骨医院骨科接受医治者,45例股骨颈骨折患者,按随机数字表法分为对照组和观察组,其中对照组22例,观察组23例。2组均进行手术,术后对照组给予常规抗感染治疗,观察组在对照组的基础上给予血府逐瘀汤治疗。2组均治疗3个月。比较2组患者治疗前后的中医证候评分、血清IGF-1、VEGF、BMP-2水平及治疗期间的并发症。结果治疗后2组患者的肿胀、疼痛、便秘和口渴等评分较治疗前皆显著降低,且观察组较对照组明显下降(P <0.05);治疗后2组患者的血清VEGF、BMP-2、IGF-1水平较治疗前显著升高,且观察组较对照组明显升高(P <0.05);治疗期间观察组患者的不良反应总发生率(8.70%)较对照组(27.27%)明显降低(P <0.05)。结论血府逐瘀汤治疗可以降低股骨颈骨折患者术后并发症的发生率,同时促进骨折部位周围血管的再生,进而促进骨折愈合。

Objective To explore the effect of Xuefu Zhuyu decoction on serum IGF-1,VEGF,BMP-2 levels and prognosis of patients with femoral neck fracture. Methods A total of 45 invalids with femoral neck fracture who received treatment in orthopedics department of Qingdao Chengyang Guzhen Orthopedic Hospital from December 2019 to September 2020 were divided into control group and observation group according to random number table method,of which 22 cases were in the control group and 23 cases were in the observation group. Both groups were operated on,the control group was given traditional anti-inflammatory therapy,and the observation group was given Xuefu Zhuyu decoction on the basis of the control group. Both groups were treated for 3 months. The traditional Chinese medicine syndrome scores,serum levels of IGF-1,VEGF,BMP-2 before and after treatment and complications during the treatment were compared between 2 groups. Results After treatment,the scores of swelling,pain,constipation and thirst in 2 groups were significantly lower than those before treatment,and the observation group was significantly more reduce than the control group( P < 0. 05). The levels of serum VEGF,BMP-2 and IGF-1 in 2 groups after treatment were significantly higher than before treatment,and the observation group was significantly higher than the control group( P < 0. 05).After treatment,the total incidence of observation group( 8. 70%) was significantly more reduce than that of control group( 27. 27%)( P <0. 05). Conclusion Xuefu Zhuyu decoction can reduce the incidence of postoperative complications in invalids with femoral neck fracture,and promote the regeneration of blood vessels around the fracture site,so as to enhance the curative effect and promote fracture healing.