中药外敷配合电针对膝骨性关节炎患者血清CPR、hs-CPR、ESR水平的影响

Effect of External Application of Chinese Medicine Combined with Electro-acupuncture on Serum Levels of CPR,hs-CPR and ESR in Patients with Knee Osteoarthritis

目的通过观察自拟方中药外敷配合电针治疗对膝骨性关节炎(KOA)患者血清C反应蛋白(CPR)、超敏C反应蛋白(hs-CPR)、血沉(ESR)水平变化的影响,评价该法治疗膝骨性关节炎的临床疗效。方法将68例KOA患者按照随机数字表法分为治疗组(34例)和对照组(34例),治疗组予以自拟方中药外敷配合电针治疗,对照组予以双氯芬酸二乙胺乳胶外涂配合电针治疗,共治疗5 d后检测患者血清CPR、hs-CPR、ESR水平。结果 2组患者血清CPR、hs-CPR、ESR水平与治疗前比较均有明显改善(P <0.05),且治疗后治疗组各项指标均优于对照组(P <0.05)。结论运用自拟方中药外敷配合电针可明显抑制KOA患者炎症反应,提高临床疗效。

Objective The changes of serum C-reactive protein( CPR),hypersensitive C-reactive protein( hs-CPR) and erythrocyte sedimentation rate( ESR) were observed to evaluate the clinical efficacy of external application of traditional Chinese medicine( TCM)combined with electro-acupuncture in the treatment of knee osteoarthritis( KOA). Methods 68 patients with KOA were randomly divided into treatment group( 34 cases) and control group( 34 cases). The treatment group was treated with external application of TCM and electroacupuncture,and the control group was treated with diclofenac diethylamine emulsion and electro-acupuncture. The levels of CPR,hs-CPR,ESR were recorded before and after treatment for 5 days. Results Compared with before treatment,the levels of CPR,hs-CPR,ESR were significantly improved in both groups( P < 0. 05). Moreover,the indexes of the treatment group were better than those of the control group( P < 0. 05). Conclusion The external application of Chinese medicine combined with electro-acupuncture can significantly inhibit the inflammatory response in patients with KOA,and improve the clinical effect.