新型冠状病毒肺炎患者肛拭子和鼻拭子核酸检测结果比较分析

Comparison of results of nucleic acid detection between anal swabs and nasal swabs in confirmed cases of COVID-19

目的比较新型冠状病毒肺炎(COVID-19)确诊病例肛拭子标本和鼻拭子标本核酸检测结果的差异。方法回顾性分析深圳市第三人民医院COVID-19患者不同时间点同步采集肛拭子和鼻拭子检测核酸的结果。结果共有31例COVID-19患者46次同一时间采集的肛拭子和鼻拭子的检测结果。发病早期(0~3 d),肛拭子阳性时,鼻拭子阳性率高达4/5,随着病程延长,鼻拭子阳性率越来越低,病程进展后期(≥16 d),肛拭子阳性确诊病例的鼻拭子阳性率仅为28.6%(6/21)。结论在制定解除隔离出院的标准时,除了留取两次呼吸道标本,建议将肛拭子标本新型冠状病毒核酸检测阴性作为重要参考依据。

Objective To compare the result of nucleic acid detection between anal swabs and nasal swabs in confirmed cases of COVID-19.Methods The result of nucleic acid detection between anal swabs and nasal swabs collected simultaneously at various time points after illness onset were analyzed retrospectively.Results Totally,46 matched result of anal swabs and nasal swabs in confirmed cases of COVID-19 collected at various intervals after illness onset in 31 patients were analyzed.All the result of nucleic acid detection were positive for anal swabs.The highest concordance rate of nucleic acid positive of COVID-19(80%)between anal swabs and nasal swabs was observed 0-3 days after illness onset;while the value declined to 28.57%≥16 days after illness onset.The longer the interval between sampling and illness onset,the lower the concordance rate.Conclusions Besides two negative result from respiratory tract specimens,the negative result of anal swabs should be added as an important reference of releasing from quarantine.