非霍奇金淋巴瘤患者焦虑抑郁情况分析及与病情分期、生活质量的相关性研究

Analysis of the Status of Anxiety and Depression in Patients with Non Hodgkin’s Lymphoma and the Correlation between Them and Their Stages and Quality of Life

目的:探讨非霍奇金淋巴瘤(NHL)患者焦虑、抑郁情况,并分析二者与患者病情分期、生活质量的相关性。方法:纳入我院2017年9月~2020年9月收治的NHL患者120例作为NHL组,另选取100例健康志愿者作为对照组,针对两组受试者行焦虑自评量表(SAS)、抑郁自评量表(SDS)评分。根据病情分期将NHL患者分成Ⅰ期组(n=23)、Ⅱ期组(n=40)、Ⅲ期组(n=39)、Ⅳ期组(n=18),根据患者抑郁、焦虑发生情况分成负面情绪组(n=49)、无负面情绪组(n=71)。利用简明生活质量量表(SF-36)评估生活质量,经Logistic多元回归模型分析NHL患者负面情绪发生的影响因素。结果:NHL组的SDS、SAS评分高于对照组,且Ⅲ期、Ⅳ期组的SDS、SAS评分高于Ⅰ期、Ⅱ期组,Ⅳ期组高于Ⅲ期组(P<0.05)。负面情绪组躯体功能、躯体疼痛、躯体角色功能、情绪角色功能、心理健康、精力、总体健康评分低于无负面情绪组(P<0.05)。Pearson线性分析结果显示,SDS、SAS评分与躯体功能、躯体疼痛、躯体角色功能、情绪角色功能、心理健康、精力、总体健康评分呈负相关(P<0.05)。Logistic多元回归分析结果提示,病情分期Ⅲ~Ⅳ期是NHL患者负面情绪发生的危险因素,受教育年限>8年、家庭月收入≥5000元是预防负面情绪的保护性因素(P<0.05)。结论:NHL患者病情分期越高,则焦虑、抑郁越明显,进而降低患者生活质量。

Objective:To investigate the status of anxiety and depression in patients with non Hodgkin’s lymphoma(NHL),and to analyze the correlation between them and patients’disease stage and quality of life.Methods:120 patients with NHL in our hospital from September 2017 to September 2020 were selected as the NHL group,and 100 healthy volunteers who underwent physical examination in our hospital during the same period were selected as the control group.The self rating Depression Scale(SDS)and self rating Anxiety Scale(SAS)were used to evaluate the two groups.patients with NHL were divided into stage Ⅰ group(n=23),stage Ⅱ Group(n=40),stage Ⅲ group(n=39)and stage Ⅳ group(n=18)according to the disease stage.According to the occurrence of depression and anxiety,they were divided into negative emotion group(n=49)and no negative emotion group(n=71).The concise Quality of Life Scale(SF-36)was used to evaluate the quality of life,and the influence factors of negative emotions were analyzed by Logistic multiple regression model.Results:The SDS and SAS scores of the NHL group were higher than those of the control group,and the SDS and SAS scores of the stageⅢgroup and stage Ⅳ group were higher than those of the stageⅠgroup and stageⅡgroup,and the stage Ⅳ group was higher than the stageⅢgroup(P<0.05).The scores of physical pain,physical function,emotional role function,physical role function,energy,mental health and overall health of the negative emotion group were lower than those of the no negative emotion group(P<0.05).Pearson linear analysis showed that SDS and SAS scores were negatively correlated with physical pain,physical function,emotional role function,physical role function,energy,mental health and overall health score(P<0.05).Logistic multiple regression analysis suggested that the stage Ⅲ to Ⅳ of the disease was a risk factor for negative emotions,and education years>8 years and family monthly income≥5000 yuan were protective factors to prevent negative emotions(P<0.05).Conclusion:The higher the disease stage of patients with NHL,the more obvious the anxiety and depression,and then reduce the quality of life of patients.