抑郁情绪、生活习惯与老年高血压患者雌激素受体α表达水平的相关性分析

Depression,Lifestyle and Estrogen Receptor in Elderly Patients with HypertensionαCorrelation Analysis of Expression Level

目的:探讨抑郁情绪、生活习惯与老年高血压患者雌激素受体α(ER-α)表达水平的相关性。方法:选取我院2019年1月到2020年1月收治的82例老年高血压患者作为研究对象,将其分为观察组,另选取同期来我院体检的82名健康者,将其分为对照组,检测相关指标并进行相关性分析。结果:两组受检者BMI、空腹血糖、吸烟、饮酒、体育锻炼、喜食油腻食物、喜食咸菜或口味较重情况、HAMD评分、SDS评分以及ERαm RNA表达水平对比差异显著(P<0.05);logistic回归分析表明:BMI、吸烟、饮酒、体育锻炼、喜食咸菜或口味较重、SDS评分以及ERαm RNA表达水平为高血压独立危险因素(P<0.05);不同吸烟、饮酒水平、喜食咸菜或口味较重情况以及SDS评分水平的患者ERαm RNA表达水平对比差异显著(P<0.05);Spearman相关分析结果显示:吸烟、饮酒、喜食咸菜或口味较重与ER-α呈负相关(P<0.05),SDS评分与ER-α呈正相关(P<0.05)。结论:BMI、吸烟、饮酒、体育锻炼、喜食咸菜或口味较重、SDS评分以及ERαm RNA表达水平是高血压发生的独立危险因素,其中抑郁情绪和吸烟、饮酒、喜食咸菜或口味较重等生活习惯与ER-α表达水平明显相关,因此对于ER-α表达水平明显降低的患者要通过相关措施改善患者生活习惯,控制抑郁情绪,提升患者血压控制水平。

Objective:To explore the relationship between depression,lifestyle and estrogen receptor in elderly patients with hypertensionαThe correlation between the expression level and the expression level.Methods:82 elderly patients with hypertension who were admitted to our hospital from January 2019 to January 2020 were selected as the research objects and divided into the observation group.In addition,82 healthy people who were admitted to our hospital for physical examination during the same period were selected and divided into the control group.The relevant indicators were detected and the correlation analysis was conducted.Results:There was no significant difference in gender,age and regular nap between the observation group and the control group(P>0.05).BMI,fasting blood glucose,smoking,drinking,physical exercise,greasy food,salted vegetables or heavy taste,HAMD score,SDS score and ER score of the two groups were comparedαThere was significant difference in m RNA expression(P<0.05);Logistic regression analysis showed that:BMI,smoking,drinking,physical exercise,preference for pickles or heavy taste,SDS score and ERαThe m RNA expression level was an independent risk factor for hypertension(P<0.05);Er of patients with different degree of physical exerciseαThere was no significant difference in the m RNA expression level(P>0.05).The Er of the patients with different smoking,drinking level,preference for pickles or heavy taste and SDS score level was significantly higher than that of the control groupαThere was significant difference in m RNA expression(P<0.05);Spearman correlation analysis showed that:physical exercise and estrogen receptorαThere was no significant correlation(P>0.05).Smoking,drinking,liking pickles or heavy taste were associated with estrogen receptorαSDS score was negatively correlated with ER(P<0.05)αPositive correlation(P<0.05).Conclusion:BMI,smoking,drinking,physical exercise,preference for pickles or heavy taste,SDS score and ERαThe level of m RNA expression is an independent risk factor for hypertension,in which depression,smoking,drinking,eating pickles or heavy taste and other living habits are closely related to estrogen receptorαThe expression level of estrogen receptor was significantly correlated with that of estrogen receptorαPatients with significantly lower expression level should improve their living habits,control their depression and improve their blood pressure control level through relevant measures.