香砂六君子汤辅助化疗对腹腔镜结肠癌根治术后患者细胞免疫功能和血清肿瘤标志物的影响

Effects of Xiangsha Liujunzi Decoction Adjuvant Chemotherapy on Cellular Immune Function and Serum Tumor Markers in Patients after Laparoscopic Radical Resection of Colon Cancer

目的:观察香砂六君子汤辅助化疗对腹腔镜结肠癌根治术后患者细胞免疫功能和血清肿瘤标志物的影响。方法:前瞻性选取2019年3月-2021年3月期间来南京医科大学附属江宁医院接受治疗的85例结肠癌患者,均接受腹腔镜结肠癌根治术治疗。分组方法选用随机数字表法,分为对照组(给予化疗治疗,n=42)和研究组(给予香砂六君子汤辅助化疗治疗,n=43)。对比两组疗效、中医证候积分、细胞免疫功能、血清肿瘤标志物和不良反应发生率。结果:与对照组比较,研究组的临床总有效率明显升高(P<0.05)。两组不良反应发生率组间对比无差异(P>0.05)。研究组治疗结束后CD3^(+)、CD4^(+)/CD8^(+)、CD4^(+)高于对照组(P<0.05)。研究组治疗结束后血清癌胚抗原(CEA)、癌抗原125(CA125)、甲胎蛋白(AFP)、CD8^(+)水平低于对照组(P<0.05)。研究组治疗结束后腹痛、食少纳呆、腹胀、大便脓血评分低于对照组(P<0.05)。结论:香砂六君子汤辅助化疗治疗腹腔镜结肠癌根治术后患者,可有效促进症状改善,阻止肿瘤细胞扩散,减轻免疫抑制,具有一定的临床价值。

Objective:To observe the effects of Xiangsha Liujunzi decoction adjuvant chemotherapy on cellular immune function and serum tumor markers in patients after laparoscopic radical resection of colon cancer.Methods:85 patients with colon cancer who were treated in Jiangning Hospital Affiliated to Nanjing Medical University from March 2019 to March 2021 were prospectively selected,all received laparoscopic radical resection of colon cancer.The patients were randomly divided into control group(treated with chemotherapy,n=42)and study group(treated with Xiangsha Liujunzi decoction adjuvant chemotherapy,n=43)by random number table method.The curative effect,TCM syndrome score,cellular immune function,serum tumor markers and the incidence of adverse reactions were compared between the two groups.Results:Compared with the control group,the total clinical effective rate of the study group was significantly higher(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,CD3^(+),CD4^(+)/CD8^(+),CD4^(+) of the study group were higher than those of the control group(P<0.05).The levels of serum carcinoembryonic antigen(CEA),cancer antigen 125(CA125)and alpha fetoprotein(AFP),CD8;of the study group after treatment were lower than those of the control group(P<0.05).After treatment,the scores of abdominal pain,eat less and stay foolish,abdominal distension,purulent and bloody stool of the study group were lower than those of the control group(P<0.05).Conclusion Xiangsha Liujunzi decoction adjuvant chemotherapy in the treatment of patients after laparoscopic radical resection of colon cancer can effectively promote the improvement of symptoms,prevent the spread of tumor cells,and reduce immunosuppression,which has certain clinical value.