中国老年人肺炎球菌疫苗接种意愿影响因素的Meta分析

The influencing factors of vaccination willingness in pneumococcal vaccine in Chinese senior citizen: a Meta-analysis

目的系统评价中国老年人肺炎球菌疫苗(pneumococcal vaccine, PV)接种意愿的影响因素。方法首先检索PubMed、Cochrane Library、Web of Science、EMbase、CBM、中国知网、维普网和万方数据知识服务平台中涉及中国老年人PV接种意愿影响因素研究;再由2名研究人员独立筛选文献、质量评价和数据提取,最后进行Meta分析。结果最终纳入16篇研究,Meta分析结果显示:家庭收入(OR=1.94, 95%CI:1.21~3.09,P=0.006)、PV知晓情况(OR=1.93, 95%CI:1.12~3.33,P=0.019)、肺炎病史(OR=2.09, 95%CI:1.00~4.36,P=0.050)、医生推荐(OR=2.80, 95%CI:1.18~6.62,P=0.019)与中国老年人PV接种意愿的关系有统计学意义;而文化程度(OR=1.17, 95%CI:0.81~1.70,P=0.408)、PV接种史(OR=1.06, 95%CI:0.14~8.13,P=0.957)、是否患有慢性病(OR=1.22, 95%CI:0.76~1.97,P=0.409)与中国老年人PV接种意愿的关系无统计学意义。结论家庭收入高、知晓PV、有肺炎病史、医生推荐是中国老年人PV接种意愿的促进因素,尚不能证明文化程度、PV接种史、是否患慢性病是中国老年人PV接种意愿的影响因素。

Objective To systematically review the influencing factors of the pneumococcal vaccine(PV) vaccination willingness of the elderly in China. Methods PubMed, Cochrane Library, Web of Science, EMbase, CBM, CNKI, VIP and WanFang were searched to query the original studies. Two reviewers then screened the studies, extracted the data and assessed the quality. A Meta-analysis was then performed. Results A total of 16 studies eventually fulfilled the eligibility criteria. The pooled findings of this Meta-analysis demonstrated that family income(OR=1.94, 95% CI: 1.21-3.09, P=0.006), situation of PV information(OR=1.93, 95% CI: 1.12-3.33, P=0.019), history of pneumonia(OR=2.09, 95% CI: 1.00-4.36, P=0.050), recommended by doctors(OR=2.80, 95% CI: 1.18-6.62, P=0.019)were statistically significant in relation to influencing factors of the PV vaccination willingness of the elderly in China. There was no statistically significant difference between degree of education(OR=1.17, 95% CI: 0.81-1.70, P=0.408), history of PV vaccination(OR=1.06, 95% CI: 0.14-8.13, P=0.957), and whether to suffer from chronic disease(OR=1.22, 95% CI: 0.76-1.97, P=0.409). Conclusion Family income, situation of PV information, history of pneumonia, and recommended by doctors are promoters of PV vaccination willingness among the elderly in China;It is not proved that education level, history of PV vaccination, and chronic disease were the influencing factors of PV vaccination willingness among Chinese elderly.