摘要
In the recent issue of Nature Immunology,Li et al.present a mechanistic insight into neutrophilic cell death and its role in systemic lupus erythematosus(SLE).1 Several groups reported an altered neutrophil function and enhanced neutrophilic cell death in SLE patients that provoke a sustained interferon(IFN)production.2 In a recent issue of Nature they report that enhanced ferroptosis in neutrophils results in a breakdown of immune tolerance in SLE.1 Ferroptosis has recently been identified as a novel type of regulated cell death that is driven by lipid peroxidation.Ferroptosis is implicated in a variety of pathological contexts such as cancer,(neuro-)degenerative diseases,but also in immune-mediated diseases such as non-alcoholic steatohepatitis(NASH),diabetes,multiple sclerosis(MS),and asthma.3 Nevertheless,cell-specific functions of ferroptosis remained less clear.Neutrophils are known to spontaneously undergo cell death,which is partially related to their high ROS production.
