天然多糖及其纳米递药系统调控肿瘤微环境的研究进展

Research progress of natural polysaccharides and their nano-sized drug delivery systems in regulating tumor microenvironment

天然多糖具有较好的生物相容性和独特的肿瘤免疫调节活性,是临床重要的抗肿瘤辅助治疗药物。在药剂学领域,天然多糖既可以作为活性成分,也可以作为递药载体以及肿瘤靶向配体,并且基于多糖设计的各种新型递药系统在调控肿瘤免疫微环境中已经表现出独特的优势。本文综述了天然多糖在肿瘤微环境(tumor microenvironment,TME)的免疫调控及其纳米递药系统组装方面的研究,并对基于多糖在抗肿瘤新型递药系统领域的发展前景和面临挑战展开讨论。

Natural polysaccharides with good biocompatibility and unique tumor immunomodulatory activity are becoming an important adjuvant anticancer therapy in clinic.In the field of pharmaceutics,natural polysaccharides can be used as not only bioactive components but also drug delivery carriers,as well as tumor-targeted ligands.Besides,various novel drug delivery systems based on natural polysaccharides exhibit unique advantages in regulating tumor immune microenvironment.In this review,we summarize the progress on natural polysaccharides in tumor microenvironment(TME)regulation and the designs of nano-sized drug delivery system,and point out challenges of polysaccharide-based drug delivery systems in the future application,and also give the potential solutions for these issues.