代谢综合征与胃癌患者临床病理特征的关系

Correlation of metabolic syndrome with clinicopathological characteristics of patients with gastric cancer

目的探讨代谢综合征(MetS)与胃癌患者临床病理特征的关系。方法回顾性分析2015年1月至2018年12月山西省忻州市人民医院经病理确诊的245例胃癌患者的临床病理资料,选取同期在山西省忻州市人民医院行常规体检的462例非肿瘤患者作为对照组。分析MetS发生情况及MetS与胃癌患者临床病理特征、总生存的关系。结果245例胃癌患者中MetS的发生率为21.6%(53/245),对照组为13.6%(63/462),两者差异有统计学意义(χ^(2)=7.464,P=0.008)。胃癌患者中,MetS组与非MetS组术后肺部感染发生率分别为17.0%(9/245)和3.1%(6/462),差异有统计学意义(χ^(2)=13.874,P=0.001);两组肿瘤发生部位、切口感染、腹腔感染、吻合口瘘、胃排空障碍发生率及总生存差异均无统计学意义(均P>0.05)。胃癌患者中,MetS与组织学分化较差、TNM分期较晚相关(χ^(2)=4.242,P=0.040;χ^(2)=5.547,P=0.027)。结论胃癌患者MetS发生率高于普通人群,并且在低、未分化和进展期胃癌患者中MetS相关的代谢异常更为多见,代谢紊乱可能在胃癌发生、发展中发挥一定作用。

Objective To investigate the relationship between metabolic syndrome(MetS)and clinicopathological characteristics of patients with gastric cancer.Methods The clinicopathological data of 245 patients with gastric cancer diagnosed by pathology in Xinzhou People's Hospital of Shanxi Province from January 2015 to December 2018 were retrospectively analyzed,and 462 non⁃tumor patients who underwent routine physical examination at Xinzhou People's Hospital of Shanxi Province during the same period were selected as control group.The occurrence of MetS and the correlation of MetS with clinicopathological characteristics and overall survival of patients with gastric cancer were analyzed.Results The incidence rate of MetS in 245 patients with gastric cancer was 21.6%(53/245)and 13.6%(63/462)in the control group,and the difference between the two was statistically significant(χ^(2)=7.464,P=0.008).Among patients with gastric cancer,the incidence of postoperative lung infection in the MetS group and non⁃MetS group was 17.0%(9/245)and 3.1%(6/462),respectively,and the difference was statistically significant(χ^(2)=13.874,P=0.001);there was no significant difference in the tumor site and the incidence of incision infection,abdominal cavity infection,anastomotic leakage,gastric emptying disorder,and overall survival between the two groups(all P>0.05).In patients with gastric cancer,MetS was associated with poor histological differentiation and late TNM stage(χ^(2)=4.242,P=0.040;χ^(2)=5.547,P=0.027).Conclusions The incidence of MetS in patients with gastric cancer is higher than that in the general population,and MetS⁃related abnormalities are more common in patients with low differentiated,undifferentiated and advanced gastric cancer.MetS may play a role in the occurrence and development of gastric cancer.