前列腺癌中外周血miR-223-3p和miR-223-5p的表达水平及与临床病理特征和预后的相关性

The Expression Levels of Peripheral Blood miR-223-3p and miR-223-5p in ProstateCancer and Their Correlation with Clinicopathological Characteristics and Prognosis

目的探究外周血miR-223-3p和miR-223-5p水平与前列腺癌患者的临床病理特征和预后的关系。方法选取前列腺癌患者64例,RT-PCR检测患者血清miR-223-3p和miR-223-5p水平,多因素logistic回归分析前列腺癌患者预后的危险因素。结果患者年龄、术前PSA差异无统计学意义(P>0.05);血清miR-223-3p、miR-223-5p表达水平与Gleason评分、有无骨转移、TNM临床分期有关(P<0.05)。存活组与死亡组PCa患者的基线特征比较,死亡组的血清miR-223-3p、miR-223-5p水平显著高于存活组(P<0.05),Gleason评分≥7、有骨转移、TNM临床分期Ⅲ+Ⅳ期的患者存活率显著低于Gleason评分<7、无骨转移、Ⅰ+Ⅱ期患者(P<0.05)。多因素logistic回归分析显示,miR-223-3p、miR-223-5p水平上升为影响脑膜瘤患者预后的独立危险因素(P<0.05)。结论血清miR-223-3p和miR-223-5p水平与前列腺癌患者临床病理特征和预后相关。

Objective To explore the relationship between the levels of miR-223-3p and miR-223-5p and the clinicopathological characteristics and prognosis of prostate cancer patients.Methods 64 prostate cancer patients were selected.The serum miR-223-3p and miR-223-5p levels were detected by RT-PCR,and multivariate logistic regression was used to analyze the prognostic risk factors of prostate cancer patients.Results There was no significant difference in patient age and preoperative PSA(P>0.05);serum miR-223-3p and miR-223-5p expression levels were related to Gleason score,the presence or absence of bone metastasis,and the clinical stage of TNM(P<0.05).Comparing the baseline characteristics of PCa patients between the survival group and the death group,serum miR-223-3p and miR-223-5p levels in the death group were significantly higher than those in the survival group(P<0.05),Gleason score≥7,bone metastases,The survival rate of patients with TNM clinical stageⅢ+Ⅳstage was significantly lower than that of patients with Gleason score<7,no bone metastases,andⅠ+Ⅱstage patients(P<0.05).Multivariate logistic regression analysis showed that the increased levels of miR-223-3p and miR-223-5p were independent risk factors affecting the prognosis of meningioma patients(P<0.05).Conclusion Serum miR-223-3p and miR-223-5p levels are correlated with clinicopathological characteristics and prognosis of prostate cancer patients.