治疗相关噬血细胞综合征研究进展

Progress of treatment-related hemophagocytic syndrome

噬血细胞综合征(HPS)是一种罕见、威胁生命的炎症反应综合征,其临床特征为免疫系统过度激活,进而导致进行性器官损害。继发性HPS通常继发于感染、肿瘤、自身免疫病;很多药物治疗过程中,也可出现HPS样表现。文章就免疫检查点抑制剂、伊布替尼、拉莫三嗪等治疗相关HPS的相关研究进行综述,以期为临床提供指导。

Hemophagocytic syndrome(HPS)is a rare,life-threatening inflammatory response syndrome characterized by overactivation of the immune system,which leads to organ damage.Secondary HPS is usually triggered by infection,tumor and autoimmune disease.It has been clinically found that many HPS-like manifestations also occur during drug therapy.This article reviews the related progress of HPS induced by immune checkpoint inhibitors,ibrutinib and lamotrigine,in order to provide a guidance for clinical practice.