生脉注射液治疗冠心病心绞痛临床特征及合并用药的真实世界研究

Real World Study of Clinical Characteristics and Concomitant Medication of Shengmai Injection for Coronary Angina

目的:探索真实世界中生脉注射液治疗冠心病心绞痛的临床特征及合并用药规律。方法:对2214例冠心病心绞痛患者医院信息系统中的临床特征数据进行描述性分析,并利用关联规则算法挖掘生脉注射液治疗冠心病心绞痛的联合用药规律。结果:男性患者共996例(44.99%),少于女性的1196例(54.02%);患者的平均年龄(72.1±12.36)岁,其中66~85岁的患者最多,共1544例(69.74%);住院病情以一般者为最多,共945例(42.68%);患者的平均住院天数为(21.96±16.26)d,其中住院天数在15~28 d的患者最多,共865例(39.07%);本研究中生脉注射液用药途径主要为静脉滴注(共1768例,占79.86%);通过静脉滴注的用药方式应用生脉注射液的单次剂量平均为(54.09±18.09)mL;其中41~60 mL者最多,共1008例(57.01%);生脉注射液的平均用药(5.4±6.49)d;生脉注射液治疗冠心病心绞痛最常用的合并用药组合为丹红注射液→单硝酸异山梨酯、速效救心丸-丹红注射液→单硝酸异山梨酯、阿伐他汀→乙酰水杨酸、单硝酸异山梨酯-美托洛尔→乙酰水杨酸。结论:经过对冠心病心绞痛患者医院信息系统(HIS)数据的严格清洗以及标准化,可通过数据挖掘技术对其进行临床特征及用药规律的挖掘分析,并为临床医生提供一定的参考,具有重要的研究意义。

Objective:To explore the clinical characteristics and combined drug usage pattern of Shengmai injection for the treatment of coronary angina in real world.Methods:Data on clinical characteristics in the hospital information system of 2214 patients with coronary angina were analyzed descriptively,and the association rule algorithm was used to mine the co-medication rule of Shengmai injection for coronary angina.Results:A total of 996(44.99%)male patients and 1196(54.02%)female patients were included in the study;The average age of the patients was 72.1±12.36 years old,of which 1544 cases(69.74%)were 66~85 years old;945 cases(42.68%)were in general condition;The average hospital stay was 21.96±16.26 days,of which 865 cases(39.07%)were in 15~28 days;In this study,the main route of administration of Shengmai injection was intravenous drip(1768 cases,accounting for 79.86%);The average single dose of Shengmai injection was 54.09±18.09 mL;among them,41~60 mL was the most,with 1008 Cases(57.01%);The average course of treatment of Shengmai injection was 5.4±6.49 days;The most commonly used combination of synbiotic injection for the treatment of coronary angina were Danhong injection→isosorbide mononitrate、Suxiaojiuxin pill-Danhong injection→isosorbide mononitrate、atorvastatin→acetylsalicylic acid、isosorbide mononitrate-metoprolol→acetylsalicylic acid.Conclusion:Through the strict cleaning and standardization of HIS data of patients with angina pectoris,we can mine and analyze the clinical characteristics and medication rules of angina pectoris,and provide certain reference for clinicians,which has important research significance.