基于“水寒木郁”病机下温阳解郁方辅助治疗对帕金森病合并轻度认知障碍老年患者认知功能及脑电功能的影响

Effects of Wenyang Jieyu Decoction on Cognitive Function and EEG Function of Elderly Patients with Parkinson Disease Complicated with Mild Cognitive Impairment Under the Pathology of "Shuihan Muyu"

目的:研究在"水寒木郁"病机下使用温阳解郁方辅助治疗老年帕金森病(PD)合并轻度认知障碍患者脑电功能及认知功能的影响。方法:选取2018年10月—2020年10月127例PD合并轻度认知障碍老年患者作为研究目标,采用随机数字表法分组,对照组63例给予多巴丝肼治疗,观察组64例增加温阳解郁方辅助治疗,比较2组患者认知功能、脑神经递质、脑电功能改善情况和不良反应情况。结果:观察组治疗后蒙特利尔认知评估量表(MoCA)评分明显高于对照组,39项帕金森生存质量调查问卷(PDQ-39)评分低于对照组;观察组5-羟色胺(5-HT)、乙酰胆碱(Ach)、多巴胺(DA)等脑神经递质水平明显高于对照组;观察组脑电功能改善有效率57.81%明显高于对照组34.92%,差异均有统计学意义。2组不良反应发生率比较,差异无统计学意义。结论:温阳解郁方辅助治疗能够提高患者神经递质水平,促进认知功能恢复,改善脑电功能,效果优异,值得推广应用。

Objective:To study the effects of Wenyang Jieyu decoction in the adjuvant treatment of elderly Parkinson’s disease (PD) patients with mild cognitive impairment under the pathogenesis of “Shuihan Muyu”.Methods:From October 2018 to October 2020,127 elderly patients with PD combined with mild cognitive impairment were selected as the research target.They were grouped by random number table.63 cases in the control group were treated with dopaserizide,and 64 cases in the observation group increased The adjuvant treatment of Wenyang Jieyu decoction compares the improvement of cognitive function,brain neurotransmitter,brain electrical function and adverse reactions in the two groups.Results:After treatment,the Montreal Cognitive Assessment Scale (MoCA) scores of the observation group were significantly higher than those of the control group,and the scores of 39 Parkinson’s Quality of Life Questionnaires (PDQ-39) were lower than those of the control group;serotonin (5-HT) in the observation group,acetylcholine (Ach),dopamine (DA) and other brain neurotransmitters were significantly higher than the control group;the observation group’s EEG function improvement rate 57.81% was significantly higher than the control group 34.92%,the difference was statistically significant.There was no statistically significant difference in the incidence of adverse reactions between the two groups.Conclusion:The adjuvant treatment of Wenyang Jieyu decoction can improve the neurotransmitter level of patients,promote the recovery of cognitive function,and improve the brain electrical function.The effect is excellent and it is worthy of popularization and application.