单齿配体取代基对钌(Ⅱ)芳烃配合物光致配体解离能力的影响

Effect of Substituent of Monodentate Ligand on Ligand Photodissociation Ability of Ruthenium(Ⅱ)Arene Complexes

合成了三种钌(Ⅱ)芳烃配合物[(η^(6)-p-cymene)Ru(bpy)(py-R)]^(2+)(bpy=2,2′-联吡啶,py=吡啶,R=N(CH_(3))_(2),H,NO_(2)),通过紫外-可见吸收光谱、核磁共振、高分辨质谱及DNA凝胶电泳等手段研究了单齿配体吡啶对位取代基的推拉电子能力如何影响配合物的光致配体解离能力。研究发现,当单齿配体吡啶对位取代基为拉电子基团硝基时,配合物具有光致单齿配体解离能力及潜在的光活化抗肿瘤活性。

Three Ru(Ⅱ)arene complexes[(η^(6)-p-cymene)Ru(bpy)(py-R)]^(2+)(bpy=2,2′-bipyridine,py=pyridine,R=N(CH_(3))_(2),H,NO_(2))were synthesized,and the substituent effects on the ligand photodissociation and DNA binding of the complexes were examined by UV-Vis absorption spectroscopy,^(1)H NMR,mass-spectrography and agarose gel electrophoresis.It was found that when the 4-site substituent R of monodentate ligand pyridine is a electron withdrawing group nitro,the complex has the ability of ligand photodissociation and potential photoactivated antitumor activity.