药物化学中构效关系的教学方法研究

Study on the Teaching Method of Structure-Activity Relationships in Pharmaceutical Chemistry

构效关系是先导化合物修饰、新型药物设计的基础,在药物化学教学中具有至关重要的作用。由于其多样性和复杂性,学生的掌握情况不理想。本文针对这一问题对药物的构效关系进行归纳分类,总结为"三部分一核心多构型"三类,每一类都进行举例讲解,为学生更好地理解与掌握药物化学的构效关系提供一种可行的方式。

Structure-activity relationships(SARs)are the basis for the modification of lead compounds and the design of new drugs,and it plays a vital role in pharmaceutical chemistry.However,it is difficult to study SARs because they are multiple and complicated.We classify the SARs into three types and summarize as‘Tripartite-One core-Many configurations’.We explain each type with several drugs in order to provide a method for students learning SARs better.