Pharmacology of Active Components of Glechomae Herba in the Treatment of Bladder Cancer

[Objectives]To explore the action mechanism of Glechomae Herba in the treatment of bladder cancer through network pharmacology.[Methods]TCMSP database retrieval and literature text mining were used to find out the main chemical active components and their targets,and the"component-target"network map was constructed by Cytoscape 3.7.0 software.The CTD database was used to select targets related to bladder cancer,and the interaction between the targets of the main active components of Glechomae Herba and the targets related to bladder cancer was taken.A total of 87 targets were obtained,then imported into the STRING database to obtain PPI network,and the topological analysis of the network was conducted to find out the key targets.The key targets were introduced into the DAVID database,and the biological process and KEGG(Kyoto Encyclopedia of Genes and Genomes)pathway of the key targets in the treatment of bladder cancer were obtained.[Results]Active compound components interfere with the occurrence and development of bladder cancer possibly through bladder cancer signaling pathway,proteoglycan in cancer signaling pathway,HIF-1 signaling pathway,tumor necrosis factor signaling pathway,PI3K-Akt signaling pathway,toll-like receptor signaling pathway,node-like receptor signaling pathway,and MAPK signaling pathway,etc.[Conclusions]The pharmacological mechanism of Glechomae Herba in the treatment of bladder cancer may be realized through multiple components,multiple targets and multiple pathways.In conclusion,Glechomae Herba has certain medicinal value.