婴幼儿呼吸道合胞病毒感染与反复喘息及支气管哮喘相关机制的研究进展

Progress on the mechanism of respiratory syncytial virus infection,recurrent wheezing and bronchial asthma in infants

呼吸道合胞病毒是引起儿童呼吸道感染常见病原,其相关的下呼吸道感染与随后反复喘息和支气管哮喘相关,但具体发病机制仍不明确。近年来发现呼吸道合胞病毒感染后引起呼吸道上皮细胞损伤、炎症介质释放及机体免疫功能紊乱等参与了支气管哮喘发病机制,并且病毒感染的早期干预与抗病毒药物的应用对反复喘息及哮喘发生有一定的改善作用。因此,该文就呼吸道合胞病毒引起反复喘息及哮喘的发病机制和抗呼吸道合胞病毒药物、疫苗的作用展开综述。

Respiratory syncytial virus(RSV)is a common pathogen of respiratory tract infection in children,and its related lower respiratory tract infection is associated with subsequent repeated wheezing and bronchial asthma,but the specific pathogenesis is still unclear.In recent years,it has been found that respiratory syncytial virus infection leads to the injury of respiratory epithelial cells,the release of inflammatory mediators and the disorder of immune function,which are involved in the pathogenesis of asthma.And the early intervention of viral infection and the development of antiviral drugs will improve the occurrence of recurrent wheezing and asthma to a certain extent.Therefore,this article reviews the relationship between recurrent wheezing and asthma caused by respiratory syncytial virus and the effects of anti-respiratory syncytial virus drugs and vaccines.