他克莫司在肾病综合征患者中的疗效及对血清Toll样受体表达的影响研究

Study on the Effect of Tacrolimus in Patients with Nephrotic Syndrome and Influence for the Expression of Serum Toll-like Receptor

目的:探究与观察他克莫司在肾病综合征患者中的疗效及对血清Toll样受体表达的影响。方法:选取2020年1月-2021年1月福建省立医院的86例肾病综合征患者为研究对象,将其根据随机数字表法分为对照组和观察组,每组43例。对照组采用常规肾病综合征治疗,观察组在对照组的基础上给予他克莫司治疗。比较两组的临床总有效率、治疗前后的血清清蛋白(ALB)、总胆固醇(TC)、三酰甘油(TG)、肾功能指标[β_(2)-微球蛋白(β_(2)-MG)、血肌酐(Scr)及尿素氮(BUN)]及Toll样受体[Toll样受体2(TLR2)及Toll样受体4(TLR4)]。结果:治疗3、6个月,观察组的临床总有效率均显著高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组的ALB、TC、TG、肾功能指标及Toll样受体比较,差异均无统计学意义(P>0.05);治疗3、6个月,观察组的血清ALB均显著高于对照组,TC、TG、肾功能指标及Toll样受体均显著低于对照组,且两组的ALB、TC、TG、肾功能指标及Toll样受体水平均显著优于治疗前,差异均有统计学意义(P<0.05)。结论:他克莫司在肾病综合征患者中的疗效较好,且对血清Toll样受体表达的影响更为积极,因此在肾病综合征患者中的应用价值较高。

Objective:To investigate and observe the effect of Tacrolimus in patients with nephrotic syndrome and influence for the expression of serum Toll-like receptor.Method:A total of 86 patients with nephrotic syndrome in the Fujian Provincial Hospital from January 2020 to January 2021 were chosen as the study object,and they were divided into control group and observation group with 43 cases in each group by the random number table method.The control group was treated with routine treatment for nephrotic syndrome,and the observation group was treated with Tacrolimus on the basis of the control group.Then the total effective rates,serum albumin(ALB),total cholesterol(TC),triacylglycerol(TG),renal function indexes[β_(2)-microglobulin(β_(2)-MG),serum creatinine(Scr)and urea nitrogen(BUN)]and Toll-like receptors[Toll like receptor 2(TLR2)and Toll like receptor 4(TLR4)]before and after the treatment of two groups were compared.Result:The total effective rates of observation group after 3 and 6 months of treatment were significantly higher than those of control group,there were statistically significant differences(P<0.05).Before treatment,ALB,TC,TG,renal function indexes and Toll-like receptors of two groups were compared,there were no statistically significant differences(P>0.05);the serum ALB of observation group after 3 and 6 months of treatment were significantly higher than those of control group,TC,TG,renal function indexes and Toll-like receptors were all significantly lower than those of control group,and the levels of ALB,TC,TG,renal function indexes and toll like receptor in the two groups after 3 and 6 months of treatment were significantly better than those before treatment,there were statistically significant differences(P<0.05).Conclusion:The effect of Tacrolimus in patients with nephrotic syndrome is better,and its influence for the expression of serum Toll-like receptor are more active,so its application value in the patients with nephrotic syndrome is higher.