替硝唑联合盐酸米诺环素缓释剂治疗老年牙周病的效果及对患者IL-6、IL-8、TNF-α水平的影响

Effect of Tinidazole Combined with Minocycline Hydrochloride Sustained Release in the Treatment of Elderly Patients with Periodontal Disease and Its Effect on IL-6,IL-8 and TNF-αLevels

目的:分析替硝唑联合盐酸米诺环素缓释剂治疗老年牙周病的临床效果和安全性,以及对患者IL-6、IL-8、TNF-α水平的影响。方法:选取2018年1月-2020年1月在厦门大学附属第一医院接受治疗的老年牙周病患者120例,将其随机分为观察组与对照组,每组60例。两组患者均在基础治疗上给予替硝唑进行治疗,在此基础上,观察组联合盐酸米诺环素缓释剂进行治疗。观察两组临床治疗效果、菌斑指数(PLI)、出血指数(BI)、牙周袋深度(PD)、治疗后不良反应以及龈沟液中IL-6、IL-8、TNF-α水平变化。结果:观察组治疗总有效率为93.33%,明显高于对照组的80.00%(P<0.05)。治疗后4周,两组PLI、BI和PD均较治疗前有明显改善,观察组较对照组改善更加明显(P<0.05)。治疗后4周,两组龈沟液IL-6、IL-8及TNF-α较治疗前均有明显改善,观察组改善均较对照组更加明显(P<0.05)。治疗后,观察组不良反应发生率为8.33%,对照组不良反应发生率为3.33%,两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:替硝唑联合盐酸米诺环素缓释剂治疗老年牙周病效果良好,操作简单,杀菌效果显著,抗炎效果明显,安全性高,适宜推广使用。

Objective:To analyze the clinical effect and safety of Tinidazole combined with Minocycline Hydrochloride Sustained Release Agent in the treatment of senile periodontal disease and its effect on the levels of IL-6,IL-8 and TNF-α.Method:A total of 120 elderly patients with periodontal disease who received treatment in the First Affiliated Hospital of Xiamen University from January 2018 to January 2020 were selected,they were randomly divided into observation group and control group,60 cases in each group.Both groups were treated with Tinidazole in addition to basic treatment,on this basis,the observation group was treated with Minocycline Hydrochloride Sustained Release Agent.The clinical treatment effect,plaque index(PLI),bleeding index(BI),periodontal pocket depth(PD),adverse reactions after treatment and the levels of IL-6,IL-8 and TNF-αin gingival crevicular fluid were observed.Result:The total effective rate of observation group was 93.33%,significantly higher than 80.00%of control group(P<0.05).4 weeks after treatment,PLI,BI and PD in two groups were significantly improved compared with before treatment,and the improvement in observation group were more obvious than those in control group(P<0.05).4 weeks after treatment,IL-6,IL-8 and TNF-αin gingival crevicular fluid in both groups were significantly improved compared with before treatment,and the improvement in observation group were more obvious than those in control group(P<0.05).After treatment,the incidence of adverse reactions was 8.33%in the observation group and 3.33%in the control group,and there was no statistical significance in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Tinidazole combined with Minocycline Hydrochloride Sustained Release Agent in the treatment of senile periodontal disease has a good effect,simple operation,significant bactericidal effect,obvious anti-inflammatory effect,high safety,suitable for popularization.