乳腺癌保乳根治术对患者生存预后及血清TRACP5b、CA15-3、IL-6水平的影响

Effects of Breast-conserving Surgery on Survival Prognosis and Serum Levels of TRACP5b,CA15-3 and IL-6 in Patients with Breast Cancer

目的:研究乳腺癌保乳根治术对患者生存预后及血清抗酒石酸盐酸性磷酸酶5b(TRACP5b)、癌抗原15-3(CA15-3)及白细胞介素-6(IL-6)水平的影响。方法:选取2017年1月-2018年2月于中国人民解放军北部战区总医院接受乳腺癌根治术的85例患者作为研究对象,将其按照手术方式的差异分作观察组(n=41)和对照组(n=44)。对照组开展改良乳腺癌根治术治疗,观察组则开展保乳根治术治疗。分析两组各项围手术期指标,术后并发症发生情况,手术前后血清TRACP5b、CA15-3及IL-6水平,术后1、2、3年生存率。结果:观察组手术时长、住院康复时间均短于对照组,且术中失血量少于对照组(P<0.05)。两组术后各并发症发生率比较,差异均无统计学意义(P>0.05)。观察组术后血清TRACP5b、CA15-3及IL-6水平均低于对照组(P<0.05)。观察组术后2、3年生存率均高于对照组(P<0.05)。结论:保乳根治术应用于乳腺癌患者的治疗中效果较佳,可明显改善血清TRACP5b、CA15-3及IL-6水平,提高术后生存率。

Objective:To study the effects of breast-conserving surgery on survival prognosis and serum levels of tartrate-resistant acid phosphatase 5b(TRACP5b),oncoantigen 15-3(CA15-3)and interleukin-6(IL-6)in patients with breast cancer.Method:From January 2017 to February 2018,85 patients who underwent radical mastectomy for breast cancer in Northern Theater General Hospital of People’s Liberation Army of China were selected as the research subjects.The patients were divided into the observation group(n=41)and the control group(n=44)according to the difference of operation methods.The control group was treated with modified radical mastectomy,while the observation group was treated with breast-conserving radical mastectomy.The perioperative indexes,postoperative complications,serum TRACP5b,CA15-3 and IL-6 levels before and after surgery,and postoperative 1 year,2 years,3 years survival rate between two groups were analyzed.Result:The duration of operation and hospitalization recovery time in the observation group were shorter than those in the control group,and the intraoperative blood loss in the observation group was less than that in the control group(P<0.05).There were no significant differences in the incidence of postoperative complications between two groups(P>0.05).The levels of TRACP5b,CA15-3 and IL-6 in the observation group after surgery were lower than those in the control group(P<0.05).The 2-year and 3-year survival rates in the observation group were higher than those in the control group(P<0.05).Conclusion:Breast-conserving radical mastectomy has a better effect in the treatment of breast cancer patients,which can significantly improve the levels of serum TRACP5b,CA15-3 and IL-6,and improve the postoperative survival rate.