摘要
目的:探讨住院心力衰竭患者引发肺部感染的相关因素和使用针对性抗感染治疗对其血清脑钠肽(BNP)和C反应蛋白(CRP)水平的影响。方法:回顾性分析2015年12月-2018年12月于营口市中心医院住院接受治疗的80例心力衰竭患者的临床资料,根据患者肺部是否发生感染分为感染组(n=18)和非感染组(n=62)。两组患者在住院后均给予基础治疗,感染组在基础治疗上采用针对性抗感染治疗。分析引发肺部感染的相关因素以及感染组患者治疗前后的血清BNP和CRP水平变化。结果:感染组患者的糖尿病、高血压、吸烟史、抗生素和激素滥用、住院时间≥14 d的占比分别为61.11%、33.33%、50.00%、61.11%、77.78%,均显著高于非感染组的24.19%、11.29%、11.29%、33.87%、30.65%(P<0.05)。糖尿病、吸烟史、抗生素和激素滥用、住院时间是住院心力衰竭患者引发肺部感染的独立影响因素(P<0.05)。感染组患者治疗后的血清BNP、CRP水平均显著低于治疗前(P<0.05)。结论:糖尿病、吸烟史、抗生素和激素滥用、住院时间是住院心力衰竭患者引发肺部感染的独立影响因素,且采取针对性抗感染治疗,可以有效降低血清BNP、CRP水平。
Objective:To investigate the related factors of pulmonary infection in patients with heart failure and the effects of targeted anti-infective therapy on serum brain natriuretic peptide(BNP)and C-reactive protein(CRP)levels.Method:A retrospective analysis was performed on the clinical data of 80 patients with heart failure hospitalized in Yingkou Central Hospital from December 2015 to December 2018.The patients were divided into infection group(n=18)and non-infection group(n=62)according to the occurrence of lung infection.Both groups were given basic treatment after hospitalization,and the infection group received targeted anti-infection treatment in addition to basic treatment.The related factors causing lung infection and the changes of serum BNP and CRP levels in the infection group before and after treatment were analyzed.Result:In the infection group,the proportions of diabetes,hypertension,smoking history,antibiotic and hormone abuse,hospital stay≥14 d were 61.11%,33.33%,50.00%,61.11%,77.78%,respectively,significantly higher than 24.19%,11.29%,11.29%,33.87%,30.65%in non-infection group(P<0.05).Diabetes mellitus,smoking history,antibiotic and hormone abuse,and length of hospital stay were independent risk factors for pulmonary infection in hospitalized heart failure patients(P<0.05).After treatment,serum BNP and CRP levels in infection group were significantly lower than those before treatment(P<0.05).Conclusion:Diabetes,smoking history,antibiotics and hormone abuse,and hospitalization time are independent influencing factors of pulmonary infection in hospitalized patients with heart failure,and targeted anti-infective treatment can effectively reduce serum BNP and CRP levels.
作者
董晶晶
孙颖
陈巍
DONG Jingjing;SUN Ying;CHEN Wei(Yingkou Central Hospital,Liaoning Province,Yingkou 115000,China)
出处
《中国医学创新》
CAS
2022年第2期150-154,共5页
Medical Innovation of China
关键词
心力衰竭
肺部感染
抗感染
脑钠肽
C反应蛋白
Heart failure
Pulmonary infection
Anti-infective
Brain natriuretic peptide
C-reactive protein