铝碳酸镁联合黛力新对功能性消化不良患者5-HT及胃肠激素水平的影响

Effects of Aluminum Magnesium Carbonate Combined with Deanxit on 5-HT and Gastrointestinal Hormone Levels in Patients with Functional Dyspepsia

目的:分析铝碳酸镁联合黛力新对功能性消化不良患者5-羟色胺(5-HT)及胃肠激素[胃泌素(GAS)、一氧化氮(NO)、胃动素(MTL)]水平的影响。方法:收集2015年1月—2019年12月我院门诊就诊的80例功能性消化不良患者,随机分为对照组和观察组各40例。对照组给予铝碳酸镁治疗,观察组给予铝碳酸镁联合黛力新治疗。观察两组患者的临床疗效、血清NO、5-HT、MTL及GAS水平、汉密尔顿焦虑量表(HAMD)评分、汉密尔顿抑郁量表(HAMD)评分和消化不良症状评分。结果:观察组总有效率为97.50%,对照组总有效率为82.50%,两组患者总有效率比较,差异无统计学意义(P>0.05);治疗后,两组患者血清NO、5-HT、MTL和GAS水平明显改善(P<0.05),且观察组优于对照组(P<0.05);治疗后,两组患者HAMA和HAMD评分均较治疗前降低(P<0.05),观察组其评分低于对照组(P<0.05);两组患者上腹部烧灼感、恶心呕吐、上腹疼痛、嗳气、餐后饱胀评分均较治疗前降低(P<0.05),观察组其评分均低于对照组(P<0.05)。结论:铝碳酸镁联合黛力新治疗功能性消化不良患者效果显著,能改善5-HT及胃肠激素水平,增强胃肠动力,改善临床症状。

Objective:This study is to investigate the effects of magnesium aluminum carbonate combined with Deanxit on the levels of 5-hydroxytryptamine(5-HT)and gastrointestinal hormones gastrin(GAS),nitric oxide(NO)and motility(MTL)in patients with functional dyspepsia.Methods:80 cases with functional dyspepsia who came to our outpatient department from January 2015 to December 2019 were selected and randomly divided into two groups.The control group was treated with magnesium aluminum carbonate alone,and the observation group was treated with magnesium aluminum carbonate combined with Deanxit.The clinical efficacy,serum levels of NO,5-HT,MTL and GAS,Hamilton Anxiety Scale(HAMA)score,Hamilton Depression Scale(HAMD)score and dyspepsia symptom score were observed.Results:There were no significant differences between observation group and control group(P>0.05).After treatment,the serum levels of NO、5-HT、MTL and GAS in the two groups were significantly improved(P<0.05),and those in the observation group were better than those in the control group(P<0.05).After treatment,HAMA and HAMD scores in both groups were lower than those before treatment(P<0.05),and the scores in observation group were lower than those in control group(P<0.05).The scores of epigastric burning,nausea and vomiting,epigastric pain,belching and postprandial fullness in both groups were lower than those before treatme(P<0.05),and the scores in observation group were lower than those in control group(P<0.05)Conclusion:Magnesium aluminum carbonate combined with Deanxit has a significant effect on functional dyspepsia,which can improve the levels of 5-HT and gastrointestinal hormones and enhance gastrointestinal motility.