帕瑞昔布复合DEX超前镇痛对高龄全髋关节置换术患者术后血清IL-1β、TNF-α水平的影响

The Effect of Parecoxib Combined With DEX Preemptive Analgesia on Serum IL-1βand TNF-αLevels in Elderly Patients Undergoing Total Hip Replacement Surgery

目的研究帕瑞昔布复合右旋美托咪定(DEX)超前镇痛对高龄全髋关节置换术患者术后血清白介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平的影响。方法选择106例接受全髋关节置换术治疗的高龄患者,按随机数表法分为观察组53例和对照组53例。对照组应用DEX进行超前镇痛,观察组在其基础上同时应用帕瑞昔布。观察两组术后疼痛评分变化、炎症相关因子水平及药物不良反应。结果经过超前镇痛后,两组术后6h、12h、24h时疼痛评分均较术前下降,观察组术后6h、12h、24h时疼痛评分均低于对照组(P<0.05);观察组术后IL-1β、TNF-α水平低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论帕瑞昔布复合DEX的超前镇痛方案可显著缓解患者疼痛,有利于控制患者术后炎症水平,且不会引起严重的不良反应。

Objective To study the effect of parecoxib combined with dexmedetomidine(DEX)preemptive analgesia on serum interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)in elderly patients undergoing total hip replacement surgery.Methods A total of 106 elderly patients undergoing total hip arthroplasty were selected and divided into observation group and control group according to a random number table method,53 cases in each group.The control group was treated with DEX for preemptive analgesia,and the observation group was treated with parecoxib at the same time.The postoperative pain score changes,inflammation-related factors levels and adverse drug reactions were observed in the two groups.Results After preemptive analgesia,the pain scores at6 h,12 h,and 24 h after surgery in the two groups were lower than those before surgery.The pain scores at 6 h,12 h,and 24 h after surgery in the observation group were lower than those in the control group(P<0.05).The levels of IL-1βand TNF-αin the observation group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The preemptive analgesia of parecoxib combined with DEX can significantly alleviate patients’pain,help control the level of postoperative inflammation,and will not cause serious adverse reactions.