垂体后叶素配合卡前列素氨丁三醇防治产后出血的临床效果探析

Analysis of the Clinical Effect of Pituitrin Combined With Carprost Tromethamine in Preventing and Treating Postpartum Hemorrhage

目的探析垂体后叶素配合卡前列素氨丁三醇防治产后出血的临床效果。方法选取102例产后出血高危产妇为受试对象,按照随机数表法均分为研究组与对照组各51例。对照组采取卡前列素氨丁三醇治疗,研究组在对照组基础之上联合垂体后叶素治疗。观察产后即刻及产后24h两组产妇凝血功能[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血小板(PLT)、纤维蛋白原(Fbg)]变化,并分析比较两组产妇产后30min、2h、24h出血量、完全止血时间及产后24h内药物不良反应发生情况差异。结果产后24h,两组产妇PLT及Fbg水平均较产后即刻有显著上升,且研究组明显高于对照组(P<0.05);两组产妇PT及APTT水平均较产后即刻有显著降低,且研究组明显低于对照组(P<0.05);研究组产妇产后30min、2h及24h出血量均明显低于对照组产妇(P<0.05);研究组产妇用药后至完全止血所用时间明显低于对照组(P<0.05);产后24h内,两组产妇恶心/呕吐、头晕、腹泻发生率均无统计学差异(P>0.05)。结论垂体后叶素配合卡前列素氨丁三醇可有效治疗产后出血、改善产妇凝血功能,且安全性良好。

Objective To explore the clinical effect of pituitrin combined with carprost tromethamine in the prevention and treatment of postpartum hemorrhage.Methods A total of 102 women with high risk of postpartum hemorrhage were selected as subjects,and they were divided into study group and control group with 51 cases each according to the random number table method.The control group was treated with carboprost tromethamine,and the study group was treated with pituitrin on the basis of the control group.Observe the changes in the coagulation function(PT,APTT,PLT,Fbg)of the two groups immediately after delivery and 24 h after delivery,and analyze and compare the differences in the amount of bleeding,the time to complete hemostasis,and the occurrence of adverse drug reactions within 24 h after delivery.Results At 24 h postpartum,the levels of PLT and Fbg of the two groups of parturients were significantly higher than those immediately after delivery,and the study group was significantly higher than the control group(P<0.05).Maternal PT and APTT levels in the two groups were significantly lower than those immediately after delivery,and the study group was significantly lower than the control group(P<0.05).The 30 min,2 h and 24 h postpartum blood loss in the study group were significantly lower than those in the control group(P<0.05).The time taken by the mothers in the study group to completely stop bleeding was significantly lower than that in the control group(P<0.05).Within 24 hours after delivery,there was no significant difference in the incidence of nausea/vomiting,dizziness,and diarrhea between the two groups(P>0.05).Conclusion Pituitrin combined with carboprost tromethamine can effectively treat postpartum hemorrhage,improve the coagulation function of the parturient,and has good safety.