亟待关注精神病临床高危综合征转归预测因素

Pay more attention to the prognostic predictors of clinical high risk for psychosis

精神病临床高危综合征患者是一类具有精神病前驱症状、遗传风险、人格特质的人群,其2年内发生精神病的风险高达30%,针对此类人群的个体化发病风险预测在精神病的早期预防中具有重要意义。本文从社会心理因素、认知功能、神经影像学、神经电生理监测和预测模型等方面阐述精神病临床高危综合征转归的预测因素。

Patients at clinical high risk(CHR)for psychosis are defined as individuals who manifest prodromal symptoms or genetic risk,as well as personality traits of psychosis.The risk of developing psychosis within 2 years is as high as 30% among CHR individuals.Therefore,predicting the individual risk of the transition to psychosis in this type of population has great significance in the early prevention of psychosis.In this article,we review the prognostic predictors of CHR from the perspectives of psychosocial factors,cognitive function,neuroimaging,neuroelectrophysiology and predictive models.